دورية أكاديمية
أعرض في EDS

Three pathologic criteria for reproducible diagnosis of colonic sessile serrated lesion versus hyperplastic polyp.

التفاصيل البيبلوغرافية
العنوان: Three pathologic criteria for reproducible diagnosis of colonic sessile serrated lesion versus hyperplastic polyp.
المؤلفون: Boylan KE; Department of Pathology and ARUP Laboratories, 84112, USA. Electronic address: Katherine.boylan@hsc.utah.edu., Kanth P; Division of Gastroenterology, 84112, USA., Delker D; Division of Gastroenterology, 84112, USA., Hazel MW; Division of Gastroenterology, 84112, USA., Boucher KM; Division of Epidemiology, University of Utah, Salt Lake City, UT, 84112, USA., Affolter K; Department of Pathology and ARUP Laboratories, 84112, USA., Clayton F; Department of Pathology and ARUP Laboratories, 84112, USA., Evason KJ; Department of Pathology and ARUP Laboratories, 84112, USA., Jedrzkiewicz J; Department of Pathology and ARUP Laboratories, 84112, USA., Pletneva M; Department of Pathology and ARUP Laboratories, 84112, USA., Samowitz W; Department of Pathology and ARUP Laboratories, 84112, USA., Swanson E; Department of Pathology and ARUP Laboratories, 84112, USA., Bronner MP; Department of Pathology and ARUP Laboratories, 84112, USA.
المصدر: Human pathology [Hum Pathol] 2023 Jul; Vol. 137, pp. 25-35. Date of Electronic Publication: 2023 Apr 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: W B Saunders Country of Publication: United States NLM ID: 9421547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8392 (Electronic) Linking ISSN: 00468177 NLM ISO Abbreviation: Hum Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: Philadelphia, PA : W B Saunders
Original Publication: Philadelphia, W B. Saunders Co.
مواضيع طبية MeSH: Colonic Polyps*/pathology , Adenoma*/pathology , Colonic Neoplasms*/genetics , Colorectal Neoplasms*/pathology, Humans ; Biopsy
مستخلص: Colonic SSLs are thought to predispose to ∼30% of colonic adenocarcinomas. This increased risk, compared to benign HPs, makes their distinction vitally important. However, no gold standard exists to differentiate them, and wide observer variability is reported. To better distinguish these polyps, we investigated 94 serrated polyps (53 SSLs and 41 HPs) using an easy-to-apply pathologic scoring system that combines, for the first time, three established distinguishing features: polyp morphology, location, and size. As an additional novel approach, polyp size was assessed by serrated biopsy number compared to endoscopic size. RNA expression profiling served as an additional biomarker. The considerable morphologic overlap across serrated polyps was quantitated for the first time. Interobserver variability was assessed by 8 expert gastrointestinal pathologists. By ROC analysis, polyp size by biopsy number performed best, followed by polyp location and morphology (areas under the curves [AUCs] = 85.9%, 81.2%, and 65.9%, respectively). Optimal discrimination combined all 3 features (AUC = 92.9%). For polyp size, the biopsy number proved superior to endoscopic size (AUC = 85.9% versus 55.2%, P = .001). Interobserver variability analysis yielded the highest reported Fleiss and Kappa statistics (0.879) and percent agreement (96.8%), showing great promise toward improved diagnosis. The proposed 3-criteria pathologic system, combining size by biopsy number, location, and morphology, yields an improved, easy-to-use, and highly reproducible diagnostic approach for differentiating SSLs and HPs.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R21 CA191507 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: Hyperplastic polyp; Observer variability; Pathology; Sessile serrated lesion; Sessile serrated polyp/adenoma
تواريخ الأحداث: Date Created: 20230412 Date Completed: 20230612 Latest Revision: 20240702
رمز التحديث: 20240702
مُعرف محوري في PubMed: PMC10330587
DOI: 10.1016/j.humpath.2023.04.002
PMID: 37044202
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-8392
DOI:10.1016/j.humpath.2023.04.002