دورية أكاديمية
Xenorecognition and costimulation of porcine endothelium-derived extracellular vesicles in initiating human porcine-specific T cell immune responses.
| العنوان: | Xenorecognition and costimulation of porcine endothelium-derived extracellular vesicles in initiating human porcine-specific T cell immune responses. |
|---|---|
| المؤلفون: | Li S; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA., Anwar IJ; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA., Canning AJ; Department of Biomedical Engineering, Duke University School of Medicine, Durham, North Carolina, USA., Vo-Dinh T; Department of Biomedical Engineering, Duke University School of Medicine, Durham, North Carolina, USA., Kirk AD; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA; Department of Immunology, Duke University School of Medicine, Durham, North Carolina, USA., Xu H; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA. Electronic address: he.xu@duke.edu. |
| المصدر: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2023 Jul; Vol. 23 (7), pp. 904-919. Date of Electronic Publication: 2023 Apr 11. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York] : Elsevier Original Publication: Copenhagen : Munksgaard International Publishers, 2001- |
| مواضيع طبية MeSH: | T-Lymphocytes* , Endothelial Cells*, Humans ; Swine ; Animals ; Endothelium ; Histocompatibility Antigens Class I ; Immunity |
| مستخلص: | Porcine vascular endothelial cells (PECs) form a mechanistic centerpiece of xenograft rejection. Here, we determined that resting PECs release swine leukocyte antigen class I (SLA-I) but not swine leukocyte antigen class-II DR (SLA-DR) expressing extracellular vesicles (EVs) and investigated whether these EVs proficiently initiate xenoreactive T cell responses via direct xenorecognition and costimulation. Human T cells acquired SLA-I + EVs with or without direct contact to PECs, and these EVs colocalized with T cell receptors. Although interferon gamma-activated PECs released SLA-DR + EVs, the binding of SLA-DR + EVs to T cells was sparse. Human T cells demonstrated low levels of proliferation without direct contact to PECs, but marked T cell proliferation was induced following exposure to EVs. EV-induced proliferation proceeded independent of monocytes/macrophages, suggesting that EVs delivered both a T cell receptor signal and costimulation. Costimulation blockade targeting B7, CD40L, or CD11a significantly reduced T cell proliferation to PEC-derived EVs. These findings indicate that endothelial-derived EVs can directly initiate T cell-mediated immune responses, and suggest that inhibiting the release of SLA-I EVs from organ xenografts has the potential to modify the xenograft rejection. We propose a secondary-direct pathway for T cell activation via xenoantigen recognition/costimulation by endothelial-derived EVs. (Copyright © 2023 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved.) |
| References: | Xenotransplantation. 2017 Mar;24(2):. (PMID: 28303603) J Clin Invest. 2003 Jun;111(12):1887-95. (PMID: 12813024) J Heart Lung Transplant. 2002 Apr;21(4):474-84. (PMID: 11927225) Transplantation. 2003 Jun 27;75(12):2068-76. (PMID: 12829914) Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14888-93. (PMID: 25267620) Ann Thorac Surg. 2022 Mar;113(3):712-714. (PMID: 35168784) Blood. 2008 Oct 15;112(8):3205-16. (PMID: 18658029) Dev Comp Immunol. 2009 Mar;33(3):362-74. (PMID: 18760302) Am J Transplant. 2014 Feb;14(2):319-32. (PMID: 24472192) Immunology. 2013 Sep;140(1):39-46. (PMID: 23566228) Transpl Immunol. 2021 Aug;67:101409. (PMID: 34015463) Curr Opin Immunol. 2003 Oct;15(5):493-8. (PMID: 14499255) Blood. 2005 Jul 1;106(1):216-23. (PMID: 15790784) Clin Microbiol Rev. 2001 Jan;14(1):1-14. (PMID: 11148000) Am J Transplant. 2003 May;3(5):525-33. (PMID: 12752308) Cell Mol Life Sci. 2019 Mar;76(6):1093-1106. (PMID: 30569278) J Immunol. 2006 Jan 15;176(2):750-61. (PMID: 16393958) Nat Rev Immunol. 2013 Apr;13(4):227-42. (PMID: 23470321) Annu Rev Immunol. 2010;28:57-78. (PMID: 20307208) Am J Transplant. 2011 Jan;11(1):66-76. (PMID: 21114656) Immunology. 1996 Dec;89(4):592-8. (PMID: 9014827) Am J Transplant. 2015 May;15(5):1241-52. (PMID: 25702898) Blood. 2006 Oct 1;108(7):2257-64. (PMID: 16449531) Circulation. 2020 Oct 6;142(14):1389-1398. (PMID: 33017208) Nat Med. 2005 Jan;11(1):29-31. (PMID: 15619628) J Thromb Haemost. 2003 Nov;1(11):2434-43. (PMID: 14629480) N Engl J Med. 2022 Jul 7;387(1):35-44. (PMID: 35731912) Xenotransplantation. 2010 May-Jun;17(3):224-32. (PMID: 20636543) Am J Transplant. 2002 Apr;2(4):314-22. (PMID: 12118852) Curr Opin Immunol. 1998 Oct;10(5):525-31. (PMID: 9794840) Am J Transplant. 2022 Jan;22(1):46-57. (PMID: 34331749) Am J Cardiol. 1968 Dec;22(6):804-10. (PMID: 4880225) Transplantation. 2018 Feb;102(2):249-254. (PMID: 28846555) Immunol Rev. 1999 Feb;167:179-92. (PMID: 10319260) Crit Rev Immunol. 1996;16(4):331-58. (PMID: 8954254) Transplantation. 2001 Dec 15;72(11):1858-61. (PMID: 11740405) Nat Rev Immunol. 2007 Oct;7(10):803-15. (PMID: 17893694) Transplantation. 1993 Apr;55(4):924-31. (PMID: 8475569) J Immunol. 2004 Oct 15;173(8):4828-37. (PMID: 15470023) Am J Transplant. 2008 Dec;8(12):2516-26. (PMID: 19032222) Sci Immunol. 2019 Nov 1;4(41):. (PMID: 31676497) Immunity. 1994 Apr;1(1):57-63. (PMID: 7889399) Am J Transplant. 2005 Jul;5(7):1614-25. (PMID: 15943619) Mol Biotechnol. 2017 Oct;59(9-10):435-444. (PMID: 28698981) Transplantation. 2022 May 1;106(5):950-962. (PMID: 34387242) Am J Transplant. 2019 Aug;19(8):2174-2185. (PMID: 30821922) J Immunol. 2008 Mar 1;180(5):3081-90. (PMID: 18292531) J Immunol. 2018 Apr 15;200(8):2535-2541. (PMID: 29491008) Sci Transl Med. 2020 Oct 14;12(565):. (PMID: 33055246) Nature. 2018 Dec;564(7736):430-433. (PMID: 30518863) Am J Transplant. 2021 Feb;21 Suppl 2:21-137. (PMID: 33595191) Transplantation. 2020 Aug;104(8):1566-1573. (PMID: 32732833) J Clin Invest. 2016 Aug 1;126(8):2805-20. (PMID: 27348586) J Exp Med. 1996 Mar 1;183(3):1161-72. (PMID: 8642258) Proc Natl Acad Sci U S A. 1987 Mar;84(5):1369-73. (PMID: 2434954) Sci Immunol. 2016 Jul 14;1(1):. (PMID: 27942611) Annu Rev Cell Dev Biol. 2014;30:255-89. (PMID: 25288114) Am J Transplant. 2020 Dec;20(12):3609-3619. (PMID: 32515087) Eur Heart J. 2011 Aug;32(16):2034-41. (PMID: 21186238) J Immunol. 1998 Aug 15;161(4):1652-8. (PMID: 9712027) J Immunol. 2010 Mar 1;184(5):2329-36. (PMID: 20139277) N Engl J Med. 2018 Sep 06;379(10):958-966. (PMID: 30184457) Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1004-9. (PMID: 15706036) Am J Transplant. 2017 Jan;17(1):60-68. (PMID: 27495898) J Thorac Cardiovasc Surg. 1998 Jun;115(6):1342-9. (PMID: 9628677) |
| معلومات مُعتمدة: | U01 AI090956 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: extracellular vesicles; porcine endothelial cells; swine leukocyte antigen; xeno-costimulation; xenorecognition; xenotransplantation |
| المشرفين على المادة: | 0 (Histocompatibility Antigens Class I) |
| تواريخ الأحداث: | Date Created: 20230413 Date Completed: 20230704 Latest Revision: 20240702 |
| رمز التحديث: | 20240702 |
| مُعرف محوري في PubMed: | PMC10330644 |
| DOI: | 10.1016/j.ajt.2023.04.006 |
| PMID: | 37054891 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1600-6143 |
|---|---|
| DOI: | 10.1016/j.ajt.2023.04.006 |