Editorial & Opinion
أعرض في EDS

Metabolic efficiency reshapes the seminal relationship between pathogen growth rate and virulence.

التفاصيل البيبلوغرافية
العنوان: Metabolic efficiency reshapes the seminal relationship between pathogen growth rate and virulence.
المؤلفون: Lindsay RJ; Biosciences and Living Systems Institute, University of Exeter, Exeter, UK., Holder PJ; Biosciences and Living Systems Institute, University of Exeter, Exeter, UK., Talbot NJ; The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK., Gudelj I; Biosciences and Living Systems Institute, University of Exeter, Exeter, UK.
المصدر: Ecology letters [Ecol Lett] 2023 Jun; Vol. 26 (6), pp. 896-907. Date of Electronic Publication: 2023 Apr 13.
نوع المنشور: Letter
اللغة: English
بيانات الدورية: Publisher: Blackwell Publishing Country of Publication: England NLM ID: 101121949 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-0248 (Electronic) Linking ISSN: 1461023X NLM ISO Abbreviation: Ecol Lett Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, UK : Blackwell Publishing
Original Publication: Oxford, UK : [Paris, France] : Blackwell Science ; Centre national de la recherche scientifique, c1998-
مواضيع طبية MeSH: Biological Evolution*, Virulence
مستخلص: A cornerstone of classical virulence evolution theories is the assumption that pathogen growth rate is positively correlated with virulence, the amount of damage pathogens inflict on their hosts. Such theories are key for incorporating evolutionary principles into sustainable disease management strategies. Yet, empirical evidence raises doubts over this central assumption underpinning classical theories, thus undermining their generality and predictive power. In this paper, we identify a key component missing from current theories which redefines the growth-virulence relationship in a way that is consistent with data. By modifying the activity of a single metabolic gene, we engineered strains of Magnaporthe oryzae with different nutrient acquisition and growth rates. We conducted in planta infection studies and uncovered an unexpected non-monotonic relationship between growth rate and virulence that is jointly shaped by how growth rate and metabolic efficiency interact. This novel mechanistic framework paves the way for a much-needed new suite of virulence evolution theories.
(© 2023 The Authors. Ecology Letters published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: BB/T015985/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council
فهرسة مساهمة: Keywords: growth rate; metabolic efficiency; microbial ecology; plant pathogens; synthetic ecology; trade-offs; virulence
تواريخ الأحداث: Date Created: 20230414 Date Completed: 20230525 Latest Revision: 20240320
رمز التحديث: 20240320
مُعرف محوري في PubMed: PMC10947253
DOI: 10.1111/ele.14218
PMID: 37056166
قاعدة البيانات: MEDLINE
الوصف
تدمد:1461-0248
DOI:10.1111/ele.14218