دورية أكاديمية
Technetium-99m labeled core shell hyaluronate nanoparticles as tumor responsive, metastatic skeletal lesion targeted combinatorial theranostics.
| العنوان: | Technetium-99m labeled core shell hyaluronate nanoparticles as tumor responsive, metastatic skeletal lesion targeted combinatorial theranostics. |
|---|---|
| المؤلفون: | Kaur S; Nanomedicine Laboratory, Department of Biosciences & Bioengineering, Indian Institute of Technology, Bombay, Mumbai 400076, India., Balakrishnan B; Nanomedicine Laboratory, Department of Biosciences & Bioengineering, Indian Institute of Technology, Bombay, Mumbai 400076, India; Nanotherapeutics & Biosensor Section, Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India. Electronic address: bbalakrishnan512@gmail.com., Mallia MB; Radiopharmaceutical Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Mumbai 400094, India., Keshari R; Nanomedicine Laboratory, Department of Biosciences & Bioengineering, Indian Institute of Technology, Bombay, Mumbai 400076, India., Hassan PA; Nanotherapeutics & Biosensor Section, Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Mumbai 400094, India., Banerjee R; Nanomedicine Laboratory, Department of Biosciences & Bioengineering, Indian Institute of Technology, Bombay, Mumbai 400076, India. |
| المصدر: | Carbohydrate polymers [Carbohydr Polym] 2023 Jul 15; Vol. 312, pp. 120840. Date of Electronic Publication: 2023 Mar 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1992-> : Barking : Elsevier Applied Science Publishers Original Publication: London [Eng.] : Applied Science Publishers, c1981- |
| مواضيع طبية MeSH: | Nanoparticles*/chemistry , Neoplasms*, Humans ; Technetium/chemistry ; Alendronate ; Precision Medicine ; Palmitic Acid ; Glycosaminoglycans ; Cell Line, Tumor ; Tumor Microenvironment |
| مستخلص: | Achieving target specific delivery of chemotherapeutics in metastatic skeletal lesions remains a major challenge. Towards this, a dual drug loaded, radiolabeled multi-trigger responsive nanoparticles having partially oxidized hyaluronate (HADA) conjugated to alendronate shell and palmitic acid core were developed. While the hydrophobic drug, celecoxib was encapsulated in the palmitic acid core, the hydrophilic drug, doxorubicin hydrochloride was linked to the shell via a pH responsive imine linkage. Hydroxyapatite binding studies showed affinity of alendronate conjugated HADA nanoparticles to bones. Enhanced cellular uptake of the nanoparticles was achieved via HADA-CD44 receptor binding. HADA nanoparticles demonstrated trigger responsive release of encapsulated drugs in the presence of hyaluronidase, pH and glucose, present in excess in the tumor microenvironment. Efficacy of the nanoparticles for combination chemotherapy was established by >10-fold reduction in IC Competing Interests: Declaration of competing interest Authors declare no competing financial interests or personal relationships to influence the work reported in this paper. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alendronate; Bone metastasis; Celecoxib PubChem CID 2662; Doxorubicin hydrochloride PubChem CID 443939; Hyaluronate; Radiolabeling; Sodium alendronate PubChem CID 23681107; Sodium hyaluronate PubChem CID 3084049; Technetium Tc-99m PubChem CID 26476; Trigger responsive |
| المشرفين على المادة: | 7440-26-8 (Technetium) 0 (technetium Tc 99m alendronate) X1J18R4W8P (Alendronate) 2V16EO95H1 (Palmitic Acid) 0 (Glycosaminoglycans) |
| تواريخ الأحداث: | Date Created: 20230414 Date Completed: 20230418 Latest Revision: 20230418 |
| رمز التحديث: | 20230418 |
| DOI: | 10.1016/j.carbpol.2023.120840 |
| PMID: | 37059565 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!