دورية أكاديمية
[Endothelial Dysfunction in Patients With Takotsubo Syndrome and its Role in Acute and Long Terms Of the Disease].
| العنوان: | [Endothelial Dysfunction in Patients With Takotsubo Syndrome and its Role in Acute and Long Terms Of the Disease]. |
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| المؤلفون: | Evdokimov DS; Mechnikov North-Eastern State Medical University, St.- Petersburg., Feoktistova VS; Mechnikov North-Eastern State Medical University, St.- Petersburg., Boldueva SA; Mechnikov North-Eastern State Medical University, St.- Petersburg., Ermolov SY; Mechnikov North-Eastern State Medical University, St.- Petersburg., Gaykovaya LB; Mechnikov North-Eastern State Medical University, St.- Petersburg. |
| المصدر: | Kardiologiia [Kardiologiia] 2023 Mar 31; Vol. 63 (3), pp. 21-27. Date of Electronic Publication: 2023 Mar 31. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: OOO Obshchestvo spet︠s︡ialistov po serdechnoĭ nedostatochnosti Country of Publication: Russia (Federation) NLM ID: 0376351 Publication Model: Electronic Cited Medium: Print ISSN: 0022-9040 (Print) Linking ISSN: 00229040 NLM ISO Abbreviation: Kardiologiia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2017->: Moskva : OOO Obshchestvo spet︠s︡ialistov po serdechnoĭ nedostatochnosti Original Publication: Moskva. |
| مواضيع طبية MeSH: | Takotsubo Cardiomyopathy*/diagnosis , Vascular Diseases* , Hyperemia*, Humans ; Middle Aged ; Aged ; Endothelial Cells ; Biomarkers ; Endothelium, Vascular |
| مستخلص: | Aim To evaluate the endothelial function using an Endo-PAT2000 instrument before and after mental stress tests in patients with Tacotsubo syndrome (TS) during acute and long-term periods and to compare the obtained results with laboratory markers of endothelial dysfunction (ED).Material and methods This study included 45 patients with TS (mean age, 63.5±13.7 years) and 40 healthy volunteers (control group, CG). All patients of the main group during the acute period (first 7-14 days) and long-term period (at 1 and 2 years), as well as CG subjects, underwent evaluation of the endothelial function with an Endo-PAT 2000 instrument, and the reactive hyperemia index (RHI) was determined before and after mental stress tests. Also, concentrations of endothelin 1 (ET-1) and numbers of circulating endothelial cells (CEC) were measured after a two-year follow-up of TS patients.Results During the acute period of disease, all TS patients (n=45) had ED: RHI was below the threshold level of 1.67; furthermore, 42 (93.3 %) patients retained a lower RHI following mental stress. At one year (n=40), 16 (40%) patients showed ED at rest along with a significantly increased mean RHI. Mental stress produced at one year was associated with ED in 28 (70 %) TS patients. At two years (n=44), resting RHI was lower than normal in 19 (43.2 %) patients. Mental stress tests performed at two years were associated with ED in 29 (65.9 %) patients (RHI ≤1.67). Only 10% of CG subjects had a lower-than-normal RHI, which was significantly less than in the main group of TS patients during the acute and long-term periods (p<0.05). Mean values of laboratory markers for ED also were significantly different between TS patients during the long-term period of disease (n=41) and CG subjects (n=40; p<0.01).Conclusion During acute and long-term periods of disease, most of TS patients had impaired vascular reactivity both at rest and during mental stress. The laboratory markers of ED, ET-1 and CEC can be used in clinical practice for evaluation of the risk for TS. |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20230416 Date Completed: 20230418 Latest Revision: 20230418 |
| رمز التحديث: | 20240829 |
| DOI: | 10.18087/cardio.2023.3.n2364 |
| PMID: | 37061857 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-9040 |
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| DOI: | 10.18087/cardio.2023.3.n2364 |