دورية أكاديمية
Sepsis-induced Pancytopenia in an Adolescent Girl with Thyroid Storm: A Case Report
| العنوان: | Sepsis-induced Pancytopenia in an Adolescent Girl with Thyroid Storm: A Case Report |
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| المؤلفون: | Zhou Q; Fujian Maternity and Child Health Hospital, Clinic of Endocrinology, Fuzhou, China; Fujian Children’s Hospital, Clinic of Endocrinology, Fuzhou, China, Zhang LY; Fujian Medical University Union Hospital, Minimal Invasive Center, Clinic of Thyroid and Vascular Surgery, Fuzhou, China, Fu QX; Fujian Children’s Hospital, Clinic of Endocrinology, Fuzhou, China, Zou CC; Children’s Hospital of Zhejiang University School of Medicine, Clinic of Endocrinology, Hangzhou, China, Liu H; Fujian Maternity and Child Health Hospital, Clinic of Endocrinology, Fuzhou, China; Fujian Children’s Hospital, Clinic of Endocrinology, Fuzhou, China |
| المصدر: | Journal of clinical research in pediatric endocrinology [J Clin Res Pediatr Endocrinol] 2024 Sep 05; Vol. 16 (3), pp. 367-371. Date of Electronic Publication: 2023 Apr 19. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Galenos Yayınevi Country of Publication: Turkey NLM ID: 101519456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1308-5735 (Electronic) NLM ISO Abbreviation: J Clin Res Pediatr Endocrinol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Istanbul : Galenos Yayınevi Original Publication: Istanbul : Turkish Pediatric Endocrinology and Diabetes Society |
| مواضيع طبية MeSH: | Pancytopenia*/drug therapy , Pancytopenia*/diagnosis , Pancytopenia*/etiology , Thyroid Crisis*/diagnosis , Thyroid Crisis*/drug therapy , Thyroid Crisis*/complications , Methimazole*/therapeutic use , Methimazole*/adverse effects , Antithyroid Agents*/therapeutic use , Antithyroid Agents*/adverse effects , Sepsis*/drug therapy , Sepsis*/complications , Sepsis*/diagnosis, Humans ; Female ; Adolescent ; Graves Disease/complications ; Graves Disease/drug therapy |
| مستخلص: | Thyroid storm is a rare but life-threatening condition mainly triggered by infection and abrupt discontinuation of antithyroid drug therapy for Graves’ disease. Pancytopenia is a rare adverse reaction to antithyroid drugs. We present a 13-year-old girl with thyroid storm and pancytopenia with symptoms similar to those of methimazole-induced pancytopenia. Although in this context the use of methimazole is still under debate, due to multiple normal complete blood counts (CBC) monitored during fever, sepsis-induced pancytopenia with thyroid storm was considered, and methimazole treatment combined with methylprednisolone and meropenem was able to resolve both pancytopenia and thyroid storm. During the period of infection and antithyroid drug therapy, close monitoring of CBC may help differentiate the aetiology of pancytopenia. This is the first paediatric case report that outlines the use of methimazole in the management of thyroid storm with pancytopenia. Competing Interests: Conflict of interest: None declared. (©Copyright 2024 by Turkish Society for Pediatric Endocrinology and Diabetes / The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House.) |
| فهرسة مساهمة: | Keywords: Thyroid storm; pancytopenia; sepsis; antithyroid drugs |
| المشرفين على المادة: | 554Z48XN5E (Methimazole) 0 (Antithyroid Agents) |
| تواريخ الأحداث: | Date Created: 20230419 Date Completed: 20240905 Latest Revision: 20240924 |
| رمز التحديث: | 20240925 |
| DOI: | 10.4274/jcrpe.galenos.2023.2022-10-3 |
| PMID: | 37074093 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1308-5735 |
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| DOI: | 10.4274/jcrpe.galenos.2023.2022-10-3 |