دورية أكاديمية
Use of Intracameral Tissue Plasminogen Activator During Uveitic Cataract Surgery.
| العنوان: | Use of Intracameral Tissue Plasminogen Activator During Uveitic Cataract Surgery. |
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| المؤلفون: | Hu WF; Flaum Eye Institute, University of Rochester, Rochester, New York, USA., Etheridge T; Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA., Larochelle MB; Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. |
| المصدر: | Ocular immunology and inflammation [Ocul Immunol Inflamm] 2024 Jul; Vol. 32 (5), pp. 673-677. Date of Electronic Publication: 2023 Apr 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9312169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-5078 (Electronic) Linking ISSN: 09273948 NLM ISO Abbreviation: Ocul Immunol Inflamm Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Buren, The Netherlands : Aeolus Press, c1993- |
| مواضيع طبية MeSH: | Tissue Plasminogen Activator*/administration & dosage , Tissue Plasminogen Activator*/therapeutic use , Visual Acuity*/physiology , Fibrinolytic Agents*/therapeutic use , Fibrinolytic Agents*/administration & dosage , Uveitis*/drug therapy, Humans ; Male ; Retrospective Studies ; Female ; Middle Aged ; Aged ; Adult ; Anterior Chamber/drug effects ; Cataract Extraction ; Aged, 80 and over |
| مستخلص: | Purpose: To report the outcomes of intracameral tissue plasminogen activator (tPA) use during uveitic cataract surgery. Design: Retrospective case series from a single United States tertiary center of 36 eyes from 31 consecutive patients with established uveitis who received intraoperative intracameral tPA during cataract surgery between 2016 and 2020. Results: Mean visual acuity (VA) improved from logMAR 1.0 ± 0.7 preoperatively to logMAR 0.7 ± 0.8 by POM12. VA improved from baseline postoperatively (POM1 p = 0.0002, POM6 p = 0.006 and POM12 p = 0.007). Minimal to no anterior chamber inflammation was achieved in 47.2% of the eyes by POW1 and 80.0% of the eyes by POM1. Mean clock-hours of posterior synechiae improved from 8.2 ± 3.8 preoperatively to 0.1 ± 0.6 by POM12. Six eyes developed hyphema and/or vitreous hemorrhage, four of which resolved spontaneously. Conclusions: Adjunctive intracameral tPA during uveitic cataract surgery improves VA and intraocular inflammation, but risks postoperative hemorrhage. Intraoperative tPA as adjunctive anti-inflammatory therapy warrants randomized prospective studies. |
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| معلومات مُعتمدة: | UL1 TR002538 United States TR NCATS NIH HHS; UM1 TR004409 United States TR NCATS NIH HHS |
| فهرسة مساهمة: | Keywords: Cataract surgery; intraocular inflammation; postoperative inflammation; tissue plasminogen activator; uveitis |
| المشرفين على المادة: | EC 3.4.21.68 (Tissue Plasminogen Activator) 0 (Fibrinolytic Agents) |
| تواريخ الأحداث: | Date Created: 20230420 Date Completed: 20240701 Latest Revision: 20240703 |
| رمز التحديث: | 20240703 |
| مُعرف محوري في PubMed: | PMC10587359 |
| DOI: | 10.1080/09273948.2023.2194410 |
| PMID: | 37079881 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1744-5078 |
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| DOI: | 10.1080/09273948.2023.2194410 |