دورية أكاديمية
The effects of female sexual hormones on the endothelial glycocalyx.
| العنوان: | The effects of female sexual hormones on the endothelial glycocalyx. |
|---|---|
| المؤلفون: | Potje SR; Department of Medical Sciences, Academic Unit of Passos, Minas Gerais State University - UEMG, Brazil. Electronic address: simone.potje@uemg.br., Martins NS; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo - USP, Brazil., Benatti MN; Serrana State Hospital, Teaching, Research and Assistance Support Foundation (FAEPA) of the Clinical Hospital, Ribeirao Preto Medical School, University of Sao Paulo - USP, Brazil., Rodrigues D; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo - USP, Brazil., Bonato VLD; Basic and Applied Immunology Program, Ribeirao Preto Medical School, University of Sao Paulo - USP, Brazil; Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo - USP, Brazil., Tostes RC; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo - USP, Brazil. Electronic address: rtostes@usp.br. |
| المصدر: | Current topics in membranes [Curr Top Membr] 2023; Vol. 91, pp. 89-137. Date of Electronic Publication: 2023 Mar 10. |
| نوع المنشور: | Review; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 9212591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1063-5823 (Print) Linking ISSN: 10635823 NLM ISO Abbreviation: Curr Top Membr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Diego : Academic Press, c1991- |
| مواضيع طبية MeSH: | Progesterone*/metabolism , Progesterone*/pharmacology , Glycocalyx*/metabolism, Pregnancy ; Humans ; Female ; Endothelial Cells/metabolism ; Vasodilation ; Estrogens/metabolism ; Estrogens/pharmacology |
| مستخلص: | The glycocalyx is a layer composed of carbohydrate side chains bound to core proteins that lines the vascular endothelium. The integrity of the glycocalyx is essential for endothelial cells' performance and vascular homeostasis. The neuroendocrine and immune systems influence the composition, maintenance, activity and degradation of the endothelial glycocalyx. The female organism has unique characteristics, and estrogen and progesterone, the main female hormones are essential to the development and physiology of the reproductive system and to the ability to develop a fetus. Female sex hormones also exert a wide variety of effects on other organs, including the vascular endothelium. They upregulate nitric oxide synthase expression and activity, decrease oxidative stress, increase vasodilation, and protect from vascular injury. This review will discuss how female hormones and pregnancy, which prompts to high levels of estrogen and progesterone, modulate the endothelial glycocalyx. Diseases prevalent in women that alter the glycocalyx, and therapeutic forms to prevent glycocalyx degradation and potential treatments that can reconstitute its structure and function will also be discussed. Competing Interests: Conflict of interest The authors declare that this manuscript was written in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Estrogen; Glycocalyx; Glycocalyx shedding; Pregnancy; Progesterone |
| المشرفين على المادة: | 4G7DS2Q64Y (Progesterone) 0 (Estrogens) |
| تواريخ الأحداث: | Date Created: 20230420 Date Completed: 20230424 Latest Revision: 20230510 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/bs.ctm.2023.02.005 |
| PMID: | 37080682 |
| قاعدة البيانات: | MEDLINE |
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