دورية أكاديمية
أعرض في EDS

Not all exons are protein coding: Addressing a common misconception.

التفاصيل البيبلوغرافية
العنوان: Not all exons are protein coding: Addressing a common misconception.
المؤلفون: Aspden JL; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.; LeedsOmics, University of Leeds, Leeds LS2 9JT, UK.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK., Wallace EWJ; Institute for Cell Biology and Centre for Engineering Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, UK., Whiffin N; Big Data Institute, University of Oxford, Oxford OX3 7LF, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
المصدر: Cell genomics [Cell Genom] 2023 Apr 12; Vol. 3 (4), pp. 100296. Date of Electronic Publication: 2023 Apr 12 (Print Publication: 2023).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier, Inc., [2021]-
مستخلص: Exons are regions of DNA that are transcribed to RNA and retained after introns are spliced out. However, the term "exon" is often misused as synonymous to "protein coding," including in some literature and textbook definitions. In contrast, only a fraction of exonic sequences are protein coding (<30% in humans). Both exons and introns are also present in untranslated regions (UTRs) and non-coding RNAs. Misuse of the term exon is problematic, for example, "whole-exome sequencing" technology targets <25% of the human exome, primarily regions that are protein coding. Here, we argue for the importance of the original definition of an exon for making functional distinctions in genetics and genomics. Further, we recommend the use of clearer language referring to coding exonic regions and non-coding exonic regions. We propose the use of coding exome sequencing, or CES, to more appropriately describe sequencing approaches that target primarily protein-coding regions rather than all transcribed regions.
Competing Interests: The authors declare no competing interests.
(© 2023 1.)
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فهرسة مساهمة: Keywords: UTRs; exome sequencing; exons; introns; non-coding RNA; splicing; untranslated regions
تواريخ الأحداث: Date Created: 20230421 Latest Revision: 20230422
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10112331
DOI: 10.1016/j.xgen.2023.100296
PMID: 37082142
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-979X
DOI:10.1016/j.xgen.2023.100296