دورية أكاديمية
Bidirectional control of parathyroid hormone and bone mass by subfornical organ.
| العنوان: | Bidirectional control of parathyroid hormone and bone mass by subfornical organ. |
|---|---|
| المؤلفون: | Zhang L; The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China., Liu N; The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China; Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China., Shao J; The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Gao D; The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Liu Y; The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Zhao Y; The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Han C; The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Chen D; Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Wang L; The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; The Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, Shenzhen, Guangdong, China; CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen, Guangdong, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, Guangdong, China., Lu WW; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China; Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. Electronic address: wwlu@hku.hk., Yang F; The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; The Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, Shenzhen, Guangdong, China; CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen, Guangdong, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, Guangdong, China. Electronic address: fan.yang@siat.ac.cn. |
| المصدر: | Neuron [Neuron] 2023 Jun 21; Vol. 111 (12), pp. 1914-1932.e6. Date of Electronic Publication: 2023 Apr 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, Mass. : Cell Press, c1988- |
| مواضيع طبية MeSH: | Subfornical Organ* , Body Fluids*, Animals ; Mice ; Parathyroid Hormone/pharmacology ; Calcium ; GABAergic Neurons |
| مستخلص: | Parathyroid hormone (PTH) is one of the most important hormones for bone turnover and calcium homeostasis. It is unclear how the central nervous system regulates PTH. The subfornical organ (SFO) lies above the third ventricle and modulates body fluid homeostasis. Through retrograde tracing, electrophysiology, and in vivo calcium imaging, we identified the SFO as an important brain nucleus that responds to serum PTH changes in mice. Chemogenetic stimulation of GABAergic neurons in SFO induces decreased serum PTH followed by a decrease in trabecular bone mass. Conversely, stimulation of glutamatergic neurons in the SFO promoted serum PTH and bone mass. Moreover, we found that the blockage of different PTH receptors in the SFO affects peripheral PTH levels and the PTH's response to calcium stimulation. Furthermore, we identified a GABAergic projection from the SFO to the paraventricular nucleus, which modulates PTH and bone mass. These findings advance our understanding of the central neural regulation of PTH at cellular and circuit level. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Neuron. 2023 Jun 21;111(12):1847-1849. (PMID: 37348456) |
| فهرسة مساهمة: | Keywords: bone; parathyroid; subfornical organ |
| المشرفين على المادة: | 0 (Parathyroid Hormone) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20230421 Date Completed: 20230626 Latest Revision: 20231121 |
| رمز التحديث: | 20231121 |
| DOI: | 10.1016/j.neuron.2023.03.030 |
| PMID: | 37084721 |
| قاعدة البيانات: | MEDLINE |
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