دورية أكاديمية
Acute coronary syndromes: hospital management of dyslipidaemia with proprotein convertase subtilisin/kexin 9 inhibitors: time to act.
| العنوان: | Acute coronary syndromes: hospital management of dyslipidaemia with proprotein convertase subtilisin/kexin 9 inhibitors: time to act. |
|---|---|
| المؤلفون: | Musumeci G; Division of Cardiology, A. O. Ordine Mauriziano Umberto I, Turin., Annibali G; Division of Cardiology, A. O. Ordine Mauriziano Umberto I, Turin., Delnevo F; Division of Cardiology, A. O. Ordine Mauriziano Umberto I, Turin. |
| المصدر: | European heart journal supplements : journal of the European Society of Cardiology [Eur Heart J Suppl] 2023 Apr 21; Vol. 25 (Suppl B), pp. B114-B118. Date of Electronic Publication: 2023 Apr 21 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 100886647 Publication Model: eCollection Cited Medium: Print ISSN: 1520-765X (Print) Linking ISSN: 1520765X NLM ISO Abbreviation: Eur Heart J Suppl Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Oxford : Oxford University Press Original Publication: London, U.K. : Saunders, c1999- |
| مستخلص: | Atherosclerotic cardiovascular disease (ASCVD) in its countless clinical presentations is, in industrialized countries, the most frequent cause of death and, in recent years, a leading role in the prevention of ASCVD has been attributed to the treatment of dyslipidaemias. If statins and ezetimibe remain the cornerstone of pharmacological treatment, an increasingly relevant role is attributed to the inhibitors of the proprotein convertase subtilisin/kexin 9 (PCSK9i), as a result of the excellent results obtained in their respective trials, not only on the reduction of low-density lipoprotein (LDL) or LDL cholesterol (LDL-C) but also on plaque stabilization and regression. The addition of PCSK9 inhibitors leads to a further reduction in LDL levels and a consequent improvement in prognosis and it is recommended in 'fast-track' administration (intrahospital/discharge) in patients with acute coronary syndromes (ACSs) or multiple cardiovascular events already on statin therapy and LDL >70 mg/dL and in statin-naïve ACS patients and LDL >140 mg/dL. By applying guidelines and fast-track, ∼25% of patients with ACS should receive PCSK9i at discharge but unfortunately patients are currently undertreated. Competing Interests: Conflict of interest: None declared. (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.) |
| References: | Arch Med Res. 2015 Jul;46(5):328-38. (PMID: 26135634) Eur Heart J. 2022 Feb 22;43(8):830-833. (PMID: 34636884) JAMA Cardiol. 2020 Aug 1;5(8):952-957. (PMID: 32432684) J Am Coll Cardiol. 2012 Dec 25;60(25):2631-9. (PMID: 23083789) Eur J Prev Cardiol. 2021 Sep 20;28(11):1279-1289. (PMID: 33580789) Lancet. 2017 Oct 28;390(10106):1962-1971. (PMID: 28859947) G Ital Cardiol (Rome). 2020 Apr;21(4):264-270. (PMID: 32202557) Circulation. 2022 Oct 11;146(15):1109-1119. (PMID: 36031810) G Ital Cardiol (Rome). 2022 Jul;23(7):553-561. (PMID: 35771021) J Am Coll Cardiol. 2019 Oct 29;74(17):2132-2146. (PMID: 31648705) Eur Heart J. 2017 Aug 21;38(32):2459-2472. (PMID: 28444290) Eur Heart J. 2020 Jan 1;41(1):111-188. (PMID: 31504418) J Am Coll Cardiol. 2015 Apr 21;65(15):1552-61. (PMID: 25770315) Lancet. 2017 Jun 24;389(10088):2473-2481. (PMID: 28476288) J Am Coll Cardiol. 2019 Nov 19;74(20):2452-2462. (PMID: 31479722) N Engl J Med. 2018 Nov 29;379(22):2097-2107. (PMID: 30403574) JAMA. 2016 Dec 13;316(22):2373-2384. (PMID: 27846344) JAMA. 2022 May 10;327(18):1771-1781. (PMID: 35368058) N Engl J Med. 2017 May 4;376(18):1713-1722. (PMID: 28304224) Cardiovasc Diagn Ther. 2021 Feb;11(1):120-129. (PMID: 33708484) Eur Heart J Acute Cardiovasc Care. 2022 Dec 27;11(12):939-949. (PMID: 36574353) |
| فهرسة مساهمة: | Keywords: ACS; Lipid-lowering therapy; PCSK9 inhibitors; Statins |
| تواريخ الأحداث: | Date Created: 20230424 Latest Revision: 20230425 |
| رمز التحديث: | 20230428 |
| مُعرف محوري في PubMed: | PMC10120980 |
| DOI: | 10.1093/eurheartjsupp/suad086 |
| PMID: | 37091651 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!