دورية أكاديمية

Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox-Catalyzed Reactions as a General Tool for Aliphatic Core Functionalization.

التفاصيل البيبلوغرافية
العنوان: Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox-Catalyzed Reactions as a General Tool for Aliphatic Core Functionalization.
المؤلفون: Fernández DF; Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States.; Pfizer Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States., González-Esguevillas M; Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States.; Pfizer Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States., Keess S; Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States., Schäfer F; Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States., Mohr J; Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States., Shavnya A; Pfizer Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States., Knauber T; Pfizer Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States., Blakemore DC; Pfizer Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States., MacMillan DWC; Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States.
المصدر: Organic letters [Org Lett] 2024 Apr 12; Vol. 26 (14), pp. 2702-2707. Date of Electronic Publication: 2023 Apr 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Chemical Society, c1999-
مواضيع طبية MeSH: Chemistry, Pharmaceutical*, Catalysis
مستخلص: C(sp 3 )-rich aliphatic motifs in drug molecules are strongly associated with clinical success. Historically, the availability of compound libraries based on C(sp 3 )-rich cores has been limited due to the challenging direct functionalization of aliphatic rings. Instead, most small molecule drug-like libraries are diversified around central aromatic rings. Herein, we present a general approach to the synthesis of diversified libraries featuring aliphatic core rings via photoredox catalysis under mild conditions.
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معلومات مُعتمدة: R35 GM134897 United States GM NIGMS NIH HHS
تواريخ الأحداث: Date Created: 20230424 Date Completed: 20240415 Latest Revision: 20240714
رمز التحديث: 20240714
مُعرف محوري في PubMed: PMC10680136
DOI: 10.1021/acs.orglett.3c00994
PMID: 37094230
قاعدة البيانات: MEDLINE
الوصف
تدمد:1523-7052
DOI:10.1021/acs.orglett.3c00994