دورية أكاديمية
Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox-Catalyzed Reactions as a General Tool for Aliphatic Core Functionalization.
العنوان: | Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox-Catalyzed Reactions as a General Tool for Aliphatic Core Functionalization. |
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المؤلفون: | Fernández DF; Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States.; Pfizer Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States., González-Esguevillas M; Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States.; Pfizer Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States., Keess S; Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States., Schäfer F; Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States., Mohr J; Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States., Shavnya A; Pfizer Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States., Knauber T; Pfizer Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States., Blakemore DC; Pfizer Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States., MacMillan DWC; Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States. |
المصدر: | Organic letters [Org Lett] 2024 Apr 12; Vol. 26 (14), pp. 2702-2707. Date of Electronic Publication: 2023 Apr 24. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c1999- |
مواضيع طبية MeSH: | Chemistry, Pharmaceutical*, Catalysis |
مستخلص: | C(sp 3 )-rich aliphatic motifs in drug molecules are strongly associated with clinical success. Historically, the availability of compound libraries based on C(sp 3 )-rich cores has been limited due to the challenging direct functionalization of aliphatic rings. Instead, most small molecule drug-like libraries are diversified around central aromatic rings. Herein, we present a general approach to the synthesis of diversified libraries featuring aliphatic core rings via photoredox catalysis under mild conditions. |
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معلومات مُعتمدة: | R35 GM134897 United States GM NIGMS NIH HHS |
تواريخ الأحداث: | Date Created: 20230424 Date Completed: 20240415 Latest Revision: 20240714 |
رمز التحديث: | 20240714 |
مُعرف محوري في PubMed: | PMC10680136 |
DOI: | 10.1021/acs.orglett.3c00994 |
PMID: | 37094230 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1523-7052 |
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DOI: | 10.1021/acs.orglett.3c00994 |