دورية أكاديمية
Microtubule competition and cell growth recenter the nucleus after anaphase in fission yeast.
| العنوان: | Microtubule competition and cell growth recenter the nucleus after anaphase in fission yeast. |
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| المؤلفون: | Bellingham-Johnstun K; Molecular Biomedical Sciences Department, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607.; Quantitative and Computational Developmental Biology Cluster, North Carolina State University, Raleigh, NC 27607., Thorn A; Molecular Biomedical Sciences Department, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607.; Quantitative and Computational Developmental Biology Cluster, North Carolina State University, Raleigh, NC 27607., Belmonte JM; Quantitative and Computational Developmental Biology Cluster, North Carolina State University, Raleigh, NC 27607.; Physics Department, College of Sciences, North Carolina State University, Raleigh, NC 27607., Laplante C; Molecular Biomedical Sciences Department, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607.; Quantitative and Computational Developmental Biology Cluster, North Carolina State University, Raleigh, NC 27607. |
| المصدر: | Molecular biology of the cell [Mol Biol Cell] 2023 Jul 01; Vol. 34 (8), pp. ar77. Date of Electronic Publication: 2023 Apr 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Cell Biology Country of Publication: United States NLM ID: 9201390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-4586 (Electronic) Linking ISSN: 10591524 NLM ISO Abbreviation: Mol Biol Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, MD : American Society for Cell Biology, c1992- |
| مواضيع طبية MeSH: | Anaphase* , Schizosaccharomyces*, Humans ; Infant, Newborn ; Microtubules/metabolism ; Cell Cycle ; Cytoskeleton ; Cell Nucleus ; Spindle Apparatus |
| مستخلص: | Cells actively position their nuclei based on their activity. In fission yeast, microtubule-dependent nuclear centering is critical for symmetrical cell division. After spindle disassembly at the end of anaphase, the nucleus recenters over an ∼90-min period, approximately half of the duration of the cell cycle. Live-cell and simulation experiments support the cooperation of two distinct microtubule competition mechanisms in the slow recentering of the nucleus. First, a push-push mechanism acts from spindle disassembly to septation and involves the opposing actions of the mitotic spindle pole body microtubules that push the nucleus away from the ends of the cell, while a postanaphase array of microtubules baskets the nucleus and limits its migration toward the division plane. Second, a slow-and-grow mechanism slowly centers the nucleus in the newborn cell by a combination of microtubule competition and asymmetric cell growth. Our work underlines how intrinsic properties of microtubules differently impact nuclear positioning according to microtubule network organization and cell size. |
| التعليقات: | Update of: bioRxiv. 2023 Feb 01;:. (PMID: 36778333) |
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| معلومات مُعتمدة: | R01 GM134254 United States GM NIGMS NIH HHS |
| تواريخ الأحداث: | Date Created: 20230426 Date Completed: 20230622 Latest Revision: 20230917 |
| رمز التحديث: | 20230917 |
| مُعرف محوري في PubMed: | PMC10398876 |
| DOI: | 10.1091/mbc.E23-01-0034 |
| PMID: | 37099380 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1939-4586 |
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| DOI: | 10.1091/mbc.E23-01-0034 |