دورية أكاديمية
أعرض في EDS

The impact of race and age on response to neoadjuvant therapy and long-term outcomes in Black and White women with early-stage breast cancer.

التفاصيل البيبلوغرافية
العنوان: The impact of race and age on response to neoadjuvant therapy and long-term outcomes in Black and White women with early-stage breast cancer.
المؤلفون: Terman E; Pritzker School of Medicine, The University of Chicago, Chicago, USA., Sheade J; Department of Medicine, Section of Hematology and Oncology, The University of Chicago, Chicago, USA., Zhao F; Department of Public Health Sciences, The University of Chicago, Chicago, USA., Howard FM; Department of Medicine, Section of Hematology and Oncology, The University of Chicago, Chicago, USA., Jaskowiak N; Department of Surgery, The University of Chicago, Chicago, USA., Tseng J; Department of Surgery, City of Hope Orange County, Irvine, USA., Chen N; Department of Medicine, Section of Hematology and Oncology, The University of Chicago, Chicago, USA., Hahn O; Department of Medicine, Section of Hematology and Oncology, The University of Chicago, Chicago, USA., Fleming G; Department of Medicine, Section of Hematology and Oncology, The University of Chicago, Chicago, USA., Huo D; Department of Public Health Sciences, The University of Chicago, Chicago, USA., Nanda R; Department of Medicine, Section of Hematology and Oncology, The University of Chicago, Chicago, USA. rnanda@medicine.bsd.uchicago.edu.
المصدر: Breast cancer research and treatment [Breast Cancer Res Treat] 2023 Jul; Vol. 200 (1), pp. 75-83. Date of Electronic Publication: 2023 Apr 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE
أسماء مطبوعة: Publication: Dordrecht : Kluwer Academic
Original Publication: The Hague ; Boston : M. Nijhoff, c1981-
مواضيع طبية MeSH: Breast Neoplasms*/ethnology , Breast Neoplasms*/pathology , Racial Groups* , Age Factors*, Female ; Humans ; Black or African American ; Cohort Studies ; Neoadjuvant Therapy ; White ; Adult ; Middle Aged
مستخلص: Purpose: There are a paucity of data and a pressing need to evaluate response to neoadjuvant chemotherapy (NACT) and determine long-term outcomes in young Black women with early-stage breast cancer (EBC).
Methods: We analyzed data from 2196 Black and White women with EBC treated at the University of Chicago over the last 2 decades. Patients were divided into groups based on race and age at diagnosis: Black women [Formula: see text] 40 years, White women [Formula: see text] 40 years, Black women [Formula: see text] 55 years, and White women [Formula: see text] 55 years. Pathological complete response rate (pCR) was analyzed using logistic regression. Overall survival (OS) and disease-free survival (DFS) were analyzed using Cox proportional hazard and piecewise Cox models.
Results: Young Black women had the highest risk of recurrence, which was 22% higher than young White women (p = 0.434) and 76% higher than older Black women (p = 0.008). These age/racial differences in recurrence rates were not statistically significant after adjusting for subtype, stage, and grade. In terms of OS, older Black women had the worst outcome. In the 397 women receiving NACT, 47.5% of young White women achieved pCR, compared to 26.8% of young Black women (p = 0.012).
Conclusions: Black women with EBC had significantly worse outcomes compared to White women in our cohort study. There is an urgent need to understand the disparities in outcomes between Black and White breast cancer patients, particularly in young women where the disparity in outcome is the greatest.
(© 2023. The Author(s).)
التعليقات: Update of: Res Sq. 2023 Mar 16;:. (PMID: 36993723)
Comment in: Breast Cancer Res Treat. 2023 Aug;201(1):149-150. (PMID: 37331985)
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معلومات مُعتمدة: NCI-SOAR Grant#1R25CA240134-01 Foundation for the National Institutes of Health; P20CA233307 Foundation for the National Institutes of Health; Summer Research Program 2021 Pritzker School of Medicine
فهرسة مساهمة: Keywords: Black women; Disparities; Neoadjuvant chemotherapy; Pathological complete response; Young women
تواريخ الأحداث: Date Created: 20230429 Date Completed: 20230530 Latest Revision: 20230629
رمز التحديث: 20230629
مُعرف محوري في PubMed: PMC10224832
DOI: 10.1007/s10549-023-06943-x
PMID: 37120458
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-7217
DOI:10.1007/s10549-023-06943-x