دورية أكاديمية
The molecular characterization of colistin-resistant isolates of Acinetobacter baumannii from patients at intensive care units.
| العنوان: | The molecular characterization of colistin-resistant isolates of Acinetobacter baumannii from patients at intensive care units. |
|---|---|
| المؤلفون: | Farajnia S; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Lotfi F; Department of Biological Sciences, Faculty of Basic Sciences, Higher Education Institute of Rab-Rashid, Tabriz, Iran., Dehnad A; Department of Biotechnology, East Azerbaijan Research and Education Center Agricultural and Natural Resources, Razi Vaccine and Serum Research Institute, AREEO, Tabriz, Iran., Shojaie M; Department of Biological Sciences, Faculty of Basic Sciences, Higher Education Institute of Rab-Rashid, Tabriz, Iran., Raisi R; Department of Biological Sciences, Faculty of Basic Sciences, Higher Education Institute of Rab-Rashid, Tabriz, Iran., Rahbarnia L; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Bazmani A; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Naghili B; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Shiry S; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. |
| المصدر: | Iranian journal of microbiology [Iran J Microbiol] 2022 Jun; Vol. 14 (3), pp. 319-327. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Tehran University of Medical Sciences Country of Publication: Iran NLM ID: 101518404 Publication Model: Print Cited Medium: Print ISSN: 2008-3289 (Print) Linking ISSN: 20083289 NLM ISO Abbreviation: Iran J Microbiol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Tehran : Tehran University of Medical Sciences |
| مستخلص: | Background and Objectives: The objective of this study was to determine molecular characterization and genetic diversity of colistin-resistant A. baumannii clinical isolates in Intensive Care Unit hospitalized patients. Materials and Methods: A total of 127 A. baumannii clinical isolates were evaluated for antimicrobial susceptibility. PCR reaction and sequencing were performed for the detection of mutations in pmrAB and lpx ACD genes. Results: Based on antimicrobial susceptibility testing, 40.94% and 33.85% of the isolates were MDR and XDR respectively whereas 3.93% of them were found to be PDR. Results of agar dilution MIC and E-test indicated that 76% of the isolates were sensitive to colistin. All of the isolates were positive for bla Conclusion: The present study indicated the prevalence of MDR and XDR A. baumannii isolates and the emergence of PDR isolates in the northwest portion of Iran. The appearance of colistin-resistant isolates with new mutations in pmrB, lpxACD genes indicates new resistance mechanisms. (Copyright © 2022 The Authors. Published by Tehran University of Medical Sciences.) |
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| فهرسة مساهمة: | Keywords: Acinetobacter baumannii; Beta-lactamase OXA-143; Beta-lactamase OXA-23; Beta-lactamase OXA-58; Colistin; OXA-72 carbapenemase |
| تواريخ الأحداث: | Date Created: 20230501 Latest Revision: 20230502 |
| رمز التحديث: | 20230502 |
| مُعرف محوري في PubMed: | PMC10132339 |
| DOI: | 10.18502/ijm.v14i3.9768 |
| PMID: | 37124847 |
| قاعدة البيانات: | MEDLINE |
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