دورية أكاديمية
أعرض في EDS

Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids.

التفاصيل البيبلوغرافية
العنوان: Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids.
المؤلفون: Papsdorf K; Department of Genetics, Stanford University, Stanford, CA, USA., Miklas JW; Department of Genetics, Stanford University, Stanford, CA, USA., Hosseini A; Department of Genetics, Stanford University, Stanford, CA, USA., Cabruja M; Department of Genetics, Stanford University, Stanford, CA, USA., Morrow CS; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Savini M; Department of Molecular and Human Genetics, Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA., Yu Y; Department of Molecular and Human Genetics, Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Silva-García CG; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Haseley NR; Department of Genetics, Stanford University, Stanford, CA, USA., Murphy LM; Department of Genetics, Stanford University, Stanford, CA, USA., Yao P; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., de Launoit E; Department of Genetics, Stanford University, Stanford, CA, USA., Dixon SJ; Department of Biology, Stanford University, Stanford, CA, USA., Snyder MP; Department of Genetics, Stanford University, Stanford, CA, USA., Wang MC; Department of Molecular and Human Genetics, Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Mair WB; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Brunet A; Department of Genetics, Stanford University, Stanford, CA, USA. anne.brunet@stanford.edu.; Glenn Laboratories for the Biology of Aging, Stanford University, Stanford, CA, USA. anne.brunet@stanford.edu.; Wu Tsai Institute of Neurosciences, Stanford University, Stanford, CA, USA. anne.brunet@stanford.edu.
المصدر: Nature cell biology [Nat Cell Biol] 2023 May; Vol. 25 (5), pp. 672-684. Date of Electronic Publication: 2023 May 01.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Macmillan Magazines Ltd., [1999-
مواضيع طبية MeSH: Longevity*/genetics , Peroxisomes*, Humans ; Middle Aged ; Animals ; Lipid Droplets ; Fatty Acids, Unsaturated ; Caenorhabditis elegans/genetics ; Fatty Acids
مستخلص: Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an organelle network involving lipid droplets and peroxisomes is critical for MUFA-induced longevity in Caenorhabditis elegans. MUFAs upregulate the number of lipid droplets in fat storage tissues. Increased lipid droplet number is necessary for MUFA-induced longevity and predicts remaining lifespan. Lipidomics datasets reveal that MUFAs also modify the ratio of membrane lipids and ether lipids-a signature associated with decreased lipid oxidation. In agreement with this, MUFAs decrease lipid oxidation in middle-aged individuals. Intriguingly, MUFAs upregulate not only lipid droplet number but also peroxisome number. A targeted screen identifies genes involved in the co-regulation of lipid droplets and peroxisomes, and reveals that induction of both organelles is optimal for longevity. Our study uncovers an organelle network involved in lipid homeostasis and lifespan regulation, opening new avenues for interventions to delay aging.
(© 2023. The Author(s).)
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معلومات مُعتمدة: S10 OD028536 United States OD NIH HHS; United States HHMI Howard Hughes Medical Institute; K99 AG065508 United States AG NIA NIH HHS; R01 AG044346 United States AG NIA NIH HHS; P30 DK020579 United States DK NIDDK NIH HHS; R01 AG054201 United States AG NIA NIH HHS; DP1 DK113644 United States DK NIDDK NIH HHS; R01 AG067106 United States AG NIA NIH HHS; S10 OD025004 United States OD NIH HHS
المشرفين على المادة: 0 (Fatty Acids, Unsaturated)
0 (Fatty Acids)
تواريخ الأحداث: Date Created: 20230501 Date Completed: 20230517 Latest Revision: 20240416
رمز التحديث: 20240416
مُعرف محوري في PubMed: PMC10185472
DOI: 10.1038/s41556-023-01136-6
PMID: 37127715
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-4679
DOI:10.1038/s41556-023-01136-6