دورية أكاديمية
Lipid nanoparticle-mediated drug delivery to the brain.
| العنوان: | Lipid nanoparticle-mediated drug delivery to the brain. |
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| المؤلفون: | Khare P; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, United States., Edgecomb SX; Department of Chemistry and Biochemistry, The University of Mississippi, MS, United States., Hamadani CM; Department of Chemistry and Biochemistry, The University of Mississippi, MS, United States., Tanner EEL; Department of Chemistry and Biochemistry, The University of Mississippi, MS, United States. Electronic address: eetanner@olemiss.edu., S Manickam D; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, United States. Electronic address: soundaramanickd@duq.edu. |
| المصدر: | Advanced drug delivery reviews [Adv Drug Deliv Rev] 2023 Jun; Vol. 197, pp. 114861. Date of Electronic Publication: 2023 May 06. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers, B.V Country of Publication: Netherlands NLM ID: 8710523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8294 (Electronic) Linking ISSN: 0169409X NLM ISO Abbreviation: Adv Drug Deliv Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, B.V., c1987- |
| مواضيع طبية MeSH: | COVID-19* , Nanoparticles*, Humans ; Lipids ; Liposomes ; RNA, Small Interfering/genetics ; Brain |
| مستخلص: | Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech and Moderna COVID-19 mRNA vaccines. While LNPs have been extensively studied for the delivery of RNA drugs to muscle and liver targets, their potential to deliver drugs to challenging tissue targets such as the brain remains underexplored. Multiple brain disorders currently lack safe and effective therapies and therefore repurposing LNPs could potentially be a game changer for improving drug delivery to cellular targets both at and across the blood-brain barrier (BBB). In this review, we will discuss (1) the rationale and factors involved in optimizing LNPs for brain delivery, (2) ionic liquid-coated LNPs as a potential approach for increasing LNP accumulation in the brain tissue and (3) considerations, open questions and potential opportunities in the development of LNPs for delivery to the brain. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Blood-brain barrier; Ionic liquids; Ionizable cationic lipid; Lipid nanoparticles; Red blood cell hitchhiking |
| المشرفين على المادة: | 0 (Lipid Nanoparticles) 0 (Lipids) 0 (Liposomes) 0 (RNA, Small Interfering) |
| تواريخ الأحداث: | Date Created: 20230507 Date Completed: 20230529 Latest Revision: 20230629 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.addr.2023.114861 |
| PMID: | 37150326 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-8294 |
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| DOI: | 10.1016/j.addr.2023.114861 |