دورية أكاديمية
Design and synthesis of novel bis-pyridinium based-ionic liquids as potent antiparasitic agents.
| العنوان: | Design and synthesis of novel bis-pyridinium based-ionic liquids as potent antiparasitic agents. |
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| المؤلفون: | Moneer EA; Department of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, Egypt., Bakr BA; Department of Zoology, Faculty of Science, Alexandria University, Alexandria, 21321, Egypt., Akl SH; Department of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, Egypt., Shahin YH; Department of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, Egypt., Elwakil BH; Department of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, Egypt., Hagar M; Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, 21321, Egypt., Paudel KR; Department of Oriental Medicine Resources, Mokpo National University, Muan-gun, Jeonnam, 58554, Republic of Korea., Aljuhani A; Department of Chemistry, College of Science, Taibah University, Al-Madinah Al-Munawarah, 30002, Saudi Arabia., Aouad MR; Department of Chemistry, College of Science, Taibah University, Al-Madinah Al-Munawarah, 30002, Saudi Arabia., Rezki N; Department of Chemistry, College of Science, Taibah University, Al-Madinah Al-Munawarah, 30002, Saudi Arabia. |
| المصدر: | Heliyon [Heliyon] 2023 Apr 14; Vol. 9 (4), pp. e15431. Date of Electronic Publication: 2023 Apr 14 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Elsevier Ltd, [2015]- |
| مستخلص: | Focused bis-pyridinium based-ionic liquids were successfully synthesized through the quaternization of the selected 1,2-di(pyridin-4-yl)ethane followed by metathetical anion exchange. The synthesized pyridinium derivatives were fully characterized using various NMR-spectroscopic techniques including 1 H, 13 C, 11 B, 31 P and 19 F NMR. The synthesized compounds were tested for their potential effect against Toxoplasma gondii . It was revealed that compound 5 had higher antiparasitic activity compared to other compounds. Parasitic reduction percentage reached 38, 50, 77 and 79 for groups III, IV, V and VI respectively in the liver with noticed distortion and deformation in tachyzoites' shape. Surprisingly there was no statistically significant difference between the synthesized compound 5 and the known anti-toxoplasmosis drug pyrimethamine. Histopathological study proved the effectiveness of the synthesized compound 5 on liver, spleen and brain tissues with observed better histological features compared to pyrimethamine treated group. The present investigation may pave the way to the possible use of compound 5 to replace the known drug pyrimethamine with better antiparasitic profile and fewer side effects. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors. Published by Elsevier Ltd.) |
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| فهرسة مساهمة: | Keywords: Antiparasitic agents; Dicationic ionic liquids; Ionic liquids; Toxoplasmosis infections |
| تواريخ الأحداث: | Date Created: 20230508 Latest Revision: 20230509 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10161609 |
| DOI: | 10.1016/j.heliyon.2023.e15431 |
| PMID: | 37151718 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2405-8440 |
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| DOI: | 10.1016/j.heliyon.2023.e15431 |