دورية أكاديمية
أعرض في EDS

Bacterial Vaginosis and Spontaneous Clearance of Chlamydia trachomatis in the Longitudinal Study of Vaginal Flora.

التفاصيل البيبلوغرافية
العنوان: Bacterial Vaginosis and Spontaneous Clearance of Chlamydia trachomatis in the Longitudinal Study of Vaginal Flora.
المؤلفون: Brown SE; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Tuddenham S; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Shardell MD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Klebanoff MA; Center for Perinatal Research, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA., Ghanem KG; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Brotman RM; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
المصدر: The Journal of infectious diseases [J Infect Dis] 2023 Sep 15; Vol. 228 (6), pp. 783-791.
نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
مواضيع طبية MeSH: Vaginosis, Bacterial*/complications , Chlamydia Infections*/epidemiology , Chlamydia Infections*/complications, Humans ; Female ; Chlamydia trachomatis ; Longitudinal Studies ; Vagina/microbiology
مستخلص: Background: Up to 26% of urogenital Chlamydia trachomatis infections spontaneously resolve between detection and treatment. Mechanisms governing natural resolution are unknown. We examined whether bacterial vaginosis (BV) was associated with greater chlamydia persistence versus spontaneous clearance in a large, longitudinal study.
Methods: Between 1999 and 2003, the Longitudinal Study of Vaginal Flora followed reproductive-age women quarterly for 1 year. Baseline chlamydia screening and treatment were initiated after ligase chain reaction testing became available midstudy, and unscreened endocervical samples were tested after study completion. Chlamydia clearance and persistence were defined between consecutive visits without chlamydia-active antibiotics (n = 320 persistence/n = 310 clearance). Associations between Nugent score (0-3, no BV; 4-10, intermediate/BV), Amsel-BV, and chlamydia persistence versus clearance were modeled with alternating and conditional logistic regression.
Results: Of chlamydia cases, 48% spontaneously cleared by the next visit (310/630). Nugent-intermediate/BV was associated with higher odds of chlamydia persistence (adjusted odds ratio [aOR] = 1.89; 95% confidence interval [CI], 1.30-2.74), and the findings were similar for Amsel-BV (aOR 1.39; 95% CI, .99-1.96). The association between Nugent-intermediate/BV and chlamydia persistence was stronger in a within-participant analysis of 67 participants with both clearance/persistence intervals (aOR = 4.77; 95% CI, 1.39-16.35). BV symptoms did not affect any results.
Conclusions: BV is associated with greater chlamydia persistence. Optimizing the vaginal microbiome may promote chlamydia clearance.
Competing Interests: Potential conflicts of interest. S. T. has been a consultant for Biofire Diagnostics, Roche Molecular Diagnostics, and Luca Biologics; receives royalties from UPTODATE; and has received speaker honoraria from Roche Molecular Diagnostics and Medscape. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
(© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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معلومات مُعتمدة: R01 AG069915 United States AG NIA NIH HHS; R01-AI116799 United States NH NIH HHS; Z01 HD002535 United States ImNIH Intramural NIH HHS; R01 AI167629 United States AI NIAID NIH HHS; R01 AI116799 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: bacterial vaginosis; chlamydia; natural history; spontaneous clearance; spontaneous resolution; vaginal microbiome
تواريخ الأحداث: Date Created: 20230509 Date Completed: 20230918 Latest Revision: 20240510
رمز التحديث: 20240510
مُعرف محوري في PubMed: PMC10503950
DOI: 10.1093/infdis/jiad142
PMID: 37158693
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-6613
DOI:10.1093/infdis/jiad142