دورية أكاديمية
Heterogeneity in the effect of marked weight loss on metabolic function in women with obesity.
| العنوان: | Heterogeneity in the effect of marked weight loss on metabolic function in women with obesity. |
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| المؤلفون: | Mittendorfer B; Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA., Kayser BD; Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA.; Genentech, South San Francisco, California, USA., Yoshino M; Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA., Yoshino J; Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA., Watrous JD; Department of Medicine, UCSD, La Jolla, California, USA., Jain M; Department of Medicine, UCSD, La Jolla, California, USA., Eagon JC; Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA., Patterson BW; Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA., Klein S; Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA.; Sansum Diabetes Research Institute, Santa Barbara, California, USA. |
| المصدر: | JCI insight [JCI Insight] 2023 Jun 22; Vol. 8 (12). Date of Electronic Publication: 2023 Jun 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]- |
| مواضيع طبية MeSH: | Insulin Resistance*/physiology, Humans ; Female ; Blood Glucose/metabolism ; Obesity/metabolism ; Insulin/metabolism ; Weight Loss/physiology ; Glucose |
| مستخلص: | BACKGROUNDThere is considerable heterogeneity in the effect of weight loss on metabolic function in people with obesity.METHODSWe evaluated muscle and liver insulin sensitivity, body composition, and circulating factors associated with insulin action before and after approximately 20% weight loss in women identified as "Responders" (n = 11) or "Non-responders" (n = 11), defined as the top (>75% increase) and bottom (<5% increase) quartiles of the weight loss-induced increase in glucose disposal rate (GDR) during a hyperinsulinemic-euglycemic clamp procedure, among 43 women with obesity (BMI: 44.1 ± 7.9 kg/m2).RESULTSAt baseline, GDR, which provides an index of muscle insulin sensitivity, and the hepatic insulin sensitivity index were more than 50% lower in Responders than Non-responders, but both increased much more after weight loss in Responders than Non-responders, which eliminated the differences between groups. Weight loss also caused greater decreases in intrahepatic triglyceride content and plasma adiponectin and PAI-1 concentrations in Responders than Non-responders and greater insulin-mediated suppression of plasma free fatty acids, branched-chain amino acids, and C3/C5 acylcarnitines in Non-responders than Responders, so that differences between groups at baseline were no longer present after weight loss. The effect of weight loss on total body fat mass, intra-abdominal adipose tissue volume, adipocyte size, and circulating inflammatory markers were not different between groups.CONCLUSIONThe results from our study demonstrate that the heterogeneity in the effects of marked weight loss on muscle and hepatic insulin sensitivity in people with obesity is determined by baseline insulin action, and reaches a ceiling when "normal" insulin action is achieved.TRIAL REGISTRATIONNCT00981500, NCT01299519, NCT02207777.FUNDINGNIH grants P30 DK056341, P30 DK020579, P30 DK052574, UL1 TR002345, and T32 HL13035, the American Diabetes Association (1-18-ICTS-119), the Longer Life Foundation (2019-011), and the Atkins Philanthropic Trust. |
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| معلومات مُعتمدة: | P30 DK092950 United States DK NIDDK NIH HHS; P30 DK052574 United States DK NIDDK NIH HHS; P30 DK056341 United States DK NIDDK NIH HHS; P30 DK020579 United States DK NIDDK NIH HHS; UL1 TR002345 United States TR NCATS NIH HHS; T32 HL130357 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: Metabolism; Obesity |
| المشرفين على المادة: | 0 (Blood Glucose) 0 (Insulin) IY9XDZ35W2 (Glucose) |
| تواريخ الأحداث: | Date Created: 20230509 Date Completed: 20230623 Latest Revision: 20240619 |
| رمز التحديث: | 20240619 |
| مُعرف محوري في PubMed: | PMC10371235 |
| DOI: | 10.1172/jci.insight.169541 |
| PMID: | 37159276 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2379-3708 |
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| DOI: | 10.1172/jci.insight.169541 |