دورية أكاديمية
أعرض في EDS

Combining exercise with cognitive training and vitamin D 3 to improve functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI). Results from the SYNERGIC trial.

التفاصيل البيبلوغرافية
العنوان: Combining exercise with cognitive training and vitamin D 3 to improve functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI). Results from the SYNERGIC trial.
المؤلفون: Bray NW; Cumming School of Medicine, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, T2N 1N4, Canada. nicholas.bray@ucalgary.ca.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, T2N 1N4, Canada. nicholas.bray@ucalgary.ca.; Gait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, 550 Wellington Road, Room A3-116, London, ON, N6C-0A7, Canada. nicholas.bray@ucalgary.ca., Pieruccini-Faria F; Gait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, 550 Wellington Road, Room A3-116, London, ON, N6C-0A7, Canada.; Department of Medicine, Division of Geriatric Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A-5C1, Canada., Witt ST; BrainsCAN, Western University, London, ON, N6A-3K7, Canada., Bartha R; Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A-5C1, Canada.; Robarts Research Institute, Western University, London, ON, N6A-5B7, Canada., Doherty TJ; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A-5C1, Canada.; Department of Physical Medicine and Rehabilitation, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A-5C1, Canada., Nagamatsu LS; Faculty of Health Sciences, School of Kinesiology, Western University, London, ON, N6G-2V4, Canada., Almeida QJ; Faculty of Science, Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, ON, N2L-3C5, Canada., Liu-Ambrose T; Department of Physical Therapy, University of British Columbia, Vancouver, BC, V6T-1Z3, Canada.; Centre for Aging SMART at Vancouver Coastal Health, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., Middleton LE; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, N2L-3G1, Canada., Bherer L; Department of Medicine, University of Montréal, Montréal, QC, H3T-1J4, Canada.; Research Centre, Montreal Heart Institute, Montréal, QC, H1T-1C8, Canada., Montero-Odasso M; Gait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, 550 Wellington Road, Room A3-116, London, ON, N6C-0A7, Canada. mmontero@uwo.ca.; Department of Medicine, Division of Geriatric Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A-5C1, Canada. mmontero@uwo.ca.; Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A-5C1, Canada. mmontero@uwo.ca.
المصدر: GeroScience [Geroscience] 2023 Jun; Vol. 45 (3), pp. 1967-1985. Date of Electronic Publication: 2023 May 10.
نوع المنشور: Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cham : Springer International Publishing, [2017]-
مواضيع طبية MeSH: Cognitive Dysfunction*/therapy , Dementia*, Humans ; Aged ; Aged, 80 and over ; Cholecalciferol ; Cognitive Training ; Brain ; Exercise/physiology ; Exercise/psychology
مستخلص: Changes in functional brain connectivity (FBC) may indicate how lifestyle modifications can prevent the progression to dementia; FBC identifies areas that are spatially separate but temporally synchronized in their activation and is altered in those with mild cognitive impairment (MCI), a prodromal state between healthy cognitive aging and dementia. Participants with MCI were randomly assigned to one of five study arms. Three times per week for 20-weeks, participants performed 30-min of (control) cognitive training, followed by 60-min of (control) physical exercise. Additionally, a vitamin D 3 (10,000 IU/pill) or a placebo capsule was ingested three times per week for 20-weeks. Using the CONN toolbox, we measured FBC change (Post-Pre) across four statistical models that collapsed for and/or included some or all study arms. We conducted Pearson correlations between FBC change and changes in physical and cognitive functioning. Our sample included 120 participants (mean age: 73.89 ± 6.50). Compared to the pure control, physical exercise (model one; p-False Discovery Rate (FDR) < 0.01 & < 0.05) with cognitive training (model two; p-FDR =  < 0.001), and all three interventions combined (model four; p-FDR =  < 0.01) demonstrated an increase in FBC between regions of the Default-Mode Network (i.e., hippocampus and angular gyrus). After controlling for false discovery rate, there were no significant correlations between change in connectivity and change in cognitive or physical function. Physical exercise alone appears to be as efficacious as combined interventional strategies in altering FBC, but implications for behavioral outcomes remain unclear.
(© 2023. The Author(s), under exclusive licence to American Aging Association.)
References: Neurology. 2012 Sep 25;79(13):1397-405. (PMID: 23008220)
Curr Alzheimer Res. 2019;16(11):1063-1071. (PMID: 31724514)
Mol Psychiatry. 2016 Nov;21(11):1633-1642. (PMID: 27001615)
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18760-5. (PMID: 18003904)
Nat Rev Neurosci. 2012 Jun 20;13(7):491-505. (PMID: 22714020)
Hum Brain Mapp. 1996;4(1):58-73. (PMID: 20408186)
Psychiatry Res Neuroimaging. 2020 Dec 30;306:111184. (PMID: 32950333)
Brain Struct Funct. 2017 May;222(4):1945-1957. (PMID: 27704218)
Ageing Res Rev. 2013 Jan;12(1):263-75. (PMID: 22841936)
Neuron. 2022 May 4;110(9):1446-1449. (PMID: 35512638)
Age Ageing. 2011 Jul;40(4):423-9. (PMID: 21624928)
J Neurosci. 2017 Aug 23;37(34):8142-8149. (PMID: 28733357)
Neurology. 2018 Jan 16;90(3):126-135. (PMID: 29282327)
Nat Rev Neurol. 2014 Nov;10(11):613-4. (PMID: 25330725)
Neuroimage. 2008 Feb 15;39(4):1666-81. (PMID: 18082428)
Nature. 2020 Jun;582(7810):84-88. (PMID: 32483374)
Alzheimers Dement. 2019 Jul;15(7):940-950. (PMID: 31113760)
Respir Care. 2003 Aug;48(8):783-5. (PMID: 12890299)
Sci Rep. 2019 Aug 6;9(1):11352. (PMID: 31388057)
Dement Geriatr Cogn Dis Extra. 2013 Sep 28;3(1):320-32. (PMID: 24174927)
Cereb Cortex. 2008 Aug;18(8):1856-64. (PMID: 18063564)
JAMA. 2003 May 21;289(19):2545-53. (PMID: 12759326)
Alzheimers Dement. 2011 May;7(3):270-9. (PMID: 21514249)
Gerontology. 2012;58(3):197-204. (PMID: 22056537)
J Alzheimers Dis. 2019;67(2):671-684. (PMID: 30636734)
Nature. 2022 Mar;603(7902):654-660. (PMID: 35296861)
Neuropsychologia. 2017 Feb;96:137-149. (PMID: 28093279)
J Neurosci. 2005 Aug 24;25(34):7709-17. (PMID: 16120771)
J Neurosci. 2017 May 24;37(21):5334-5344. (PMID: 28450541)
Neurobiol Aging. 2005 Feb;26(2):165-71. (PMID: 15582746)
J Gerontol B Psychol Sci Soc Sci. 2017 Sep 01;72(5):801-812. (PMID: 26603017)
Neuron. 2009 Apr 16;62(1):42-52. (PMID: 19376066)
Nat Methods. 2019 Jan;16(1):111-116. (PMID: 30532080)
Neuroimage. 2020 Jan 15;205:116225. (PMID: 31568872)
J Magn Reson Imaging. 2019 Feb;49(2):456-465. (PMID: 30635988)
J Frailty Aging. 2018;7(3):155-161. (PMID: 30095145)
Trends Cogn Sci. 2010 Jun;14(6):277-90. (PMID: 20493761)
Int J Neurosci. 2017 Jul;127(7):634-649. (PMID: 27412353)
Cancer. 2020 Sep 15;126(18):4246-4255. (PMID: 32639592)
Front Hum Neurosci. 2017 Jun 30;11:344. (PMID: 28713255)
Hum Brain Mapp. 2002 Nov;17(3):143-55. (PMID: 12391568)
Nat Neurosci. 2022 Jul;25(7):835-837. (PMID: 35710985)
Med Sci Sports Exerc. 1982;14(5):377-81. (PMID: 7154893)
Neuroimage. 2013 Oct 15;80:62-79. (PMID: 23684880)
Neuroimage. 2004 Oct;23(2):708-16. (PMID: 15488420)
J Neurosci. 2012 Jun 27;32(26):8890-9. (PMID: 22745490)
J Gerontol A Biol Sci Med Sci. 2005 Oct;60(10):1304-9. (PMID: 16282564)
Cereb Cortex. 2010 Nov;20(11):2636-46. (PMID: 20154013)
BMC Geriatr. 2018 Apr 16;18(1):93. (PMID: 29661156)
PLoS One. 2016 Dec 14;11(12):e0168534. (PMID: 27973594)
J Gerontol. 1994 Mar;49(2):M85-94. (PMID: 8126356)
Brain Sci. 2020 Oct 29;10(11):. (PMID: 33137993)
Nat Rev Neurosci. 2017 Feb;18(2):115-126. (PMID: 28053326)
Med Sci Sports Exerc. 2020 May;52(5):1057-1067. (PMID: 31876667)
Mech Ageing Dev. 2021 Mar;194:111431. (PMID: 33422561)
PLoS One. 2009 Sep 29;4(9):e7200. (PMID: 19787067)
Exerc Sport Sci Rev. 2012 Jan;40(1):4-12. (PMID: 22016147)
Brain Imaging Behav. 2012 Dec;6(4):489-501. (PMID: 22614326)
Front Neurosci. 2019 May 07;13:435. (PMID: 31133781)
Neuropsychol Rev. 2020 Dec;30(4):546-557. (PMID: 33011894)
Sci Data. 2016 Jun 21;3:160044. (PMID: 27326542)
Cortex. 2017 Jun;91:101-113. (PMID: 28077212)
Brain Connect. 2012;2(3):125-41. (PMID: 22642651)
Lancet. 2020 Aug 8;396(10248):413-446. (PMID: 32738937)
J Clin Med. 2020 Mar 09;9(3):. (PMID: 32182904)
Arch Clin Neuropsychol. 2021 Oct 13;36(7):1316-1325. (PMID: 33372951)
Annu Rev Neurosci. 2015 Jul 8;38:433-47. (PMID: 25938726)
Neuroscientist. 2019 Feb;25(1):65-85. (PMID: 29683026)
Mech Ageing Dev. 2021 Jun;196:111493. (PMID: 33887281)
Neuroimage. 2004;23 Suppl 1:S208-19. (PMID: 15501092)
J Alzheimers Dis. 2016;52(2):673-84. (PMID: 27060939)
Alzheimers Dement. 2022 Apr;18(4):700-789. (PMID: 35289055)
Geroscience. 2023 Apr;45(2):1033-1048. (PMID: 36539590)
Int Psychogeriatr. 2021 Oct;33(10):1035-1043. (PMID: 33586645)
Cortex. 2018 Feb;99:224-234. (PMID: 29287243)
Nat Neurosci. 2022 Jul;25(7):833-834. (PMID: 35790858)
Neurosci Biobehav Rev. 2010 Jul;34(8):1178-94. (PMID: 20109489)
Transl Neurodegener. 2018 Nov 07;7:26. (PMID: 30443345)
Lancet Neurol. 2019 Feb;18(2):177-184. (PMID: 30663607)
Biol Psychiatry. 2013 Sep 1;74(5):340-7. (PMID: 23290495)
J Strength Cond Res. 2016 Jan;30(1):267-75. (PMID: 26049792)
Neuroimage Clin. 2019;23:101834. (PMID: 31128522)
Health Psychol Rev. 2017 Dec;11(4):324-344. (PMID: 28460601)
Proc Natl Acad Sci U S A. 1990 Dec;87(24):9868-72. (PMID: 2124706)
Neurosci Lett. 2013 Nov 27;556:15-9. (PMID: 24120430)
Front Aging Neurosci. 2014 Mar 10;6:39. (PMID: 24653698)
Neurology. 2011 Oct 18;77(16):1524-31. (PMID: 21975202)
Annu Rev Clin Psychol. 2022 May 9;18:417-442. (PMID: 35044793)
Neuropsychol Rev. 2020 Jun;30(2):267-286. (PMID: 32529356)
PLoS One. 2012;7(7):e40588. (PMID: 22792378)
Hum Brain Mapp. 2019 Feb 1;40(2):394-406. (PMID: 30251770)
J Frailty Aging. 2020;9(2):111-117. (PMID: 32259186)
Can J Diabetes. 2021 Aug;45(6):546-552. (PMID: 33358932)
Neurosci Biobehav Rev. 2019 Jan;96:232-240. (PMID: 30543905)
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14504-9. (PMID: 14608034)
Hum Brain Mapp. 2017 Feb;38(2):938-956. (PMID: 27739612)
Neuron. 2007 Dec 6;56(5):924-35. (PMID: 18054866)
Neurology. 1998 Apr;50(4):972-8. (PMID: 9566381)
Front Aging Neurosci. 2017 Aug 11;9:267. (PMID: 28848424)
Ann Neurol. 2004 Mar;55(3):306-19. (PMID: 14991808)
معلومات مُعتمدة: MOP 211220 Canada CIHR; PJT 153100 Canada CIHR
فهرسة مساهمة: Keywords: Intervention; Mild Cognitive Impairment; Physical Exercise; Randomized Controlled Trial; fMRI
سلسلة جزيئية: ClinicalTrials.gov NCT02808676
المشرفين على المادة: 1C6V77QF41 (Cholecalciferol)
تواريخ الأحداث: Date Created: 20230510 Date Completed: 20230804 Latest Revision: 20230807
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10170058
DOI: 10.1007/s11357-023-00805-6
PMID: 37162700
قاعدة البيانات: MEDLINE
الوصف
تدمد:2509-2723
DOI:10.1007/s11357-023-00805-6