دورية أكاديمية
أعرض في EDS

COVID-19, Myocarditis and Pericarditis.

التفاصيل البيبلوغرافية
العنوان: COVID-19, Myocarditis and Pericarditis.
المؤلفون: Fairweather D; Department of Cardiovascular Medicine (D.F., D.J.B., D.N.D., L.T.C.), Mayo Clinic, Jacksonville, FL.; Department of Environmental Health Sciences and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (D.F.,).; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN (D.F., D.J.B., D.N.D.)., Beetler DJ; Department of Cardiovascular Medicine (D.F., D.J.B., D.N.D., L.T.C.), Mayo Clinic, Jacksonville, FL.; Mayo Clinic Graduate School of Biomedical Sciences (D.J.B., D.N.D.), Mayo Clinic, Jacksonville, FL.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN (D.F., D.J.B., D.N.D.)., Di Florio DN; Department of Cardiovascular Medicine (D.F., D.J.B., D.N.D., L.T.C.), Mayo Clinic, Jacksonville, FL.; Mayo Clinic Graduate School of Biomedical Sciences (D.J.B., D.N.D.), Mayo Clinic, Jacksonville, FL.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN (D.F., D.J.B., D.N.D.)., Musigk N; Deutsches Herzzentrum der Charité, Berlin, Germany (N.M., B.H.)., Heidecker B; Deutsches Herzzentrum der Charité, Berlin, Germany (N.M., B.H.)., Cooper LT Jr; Department of Cardiovascular Medicine (D.F., D.J.B., D.N.D., L.T.C.), Mayo Clinic, Jacksonville, FL.
المصدر: Circulation research [Circ Res] 2023 May 12; Vol. 132 (10), pp. 1302-1319. Date of Electronic Publication: 2023 May 11.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE
أسماء مطبوعة: Publication: Baltimore, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore, Md. Grune & Stratton.
مواضيع طبية MeSH: COVID-19* , COVID-19 Vaccines*/adverse effects , Myocarditis*/epidemiology , Myocarditis*/etiology , Pericarditis*/epidemiology, Female ; Humans ; Male ; SARS-CoV-2
مستخلص: Viral infections are a leading cause of myocarditis and pericarditis worldwide, conditions that frequently coexist. Myocarditis and pericarditis were some of the early comorbidities associated with SARS-CoV-2 infection and COVID-19. Many epidemiologic studies have been conducted since that time concluding that SARS-CoV-2 increased the incidence of myocarditis/pericarditis at least 15× over pre-COVID levels although the condition remains rare. The incidence of myocarditis pre-COVID was reported at 1 to 10 cases/100 000 individuals and with COVID ranging from 150 to 4000 cases/100 000 individuals. Before COVID-19, some vaccines were reported to cause myocarditis and pericarditis in rare cases, but the use of novel mRNA platforms led to a higher number of reported cases than with previous platforms providing new insight into potential pathogenic mechanisms. The incidence of COVID-19 vaccine-associated myocarditis/pericarditis covers a large range depending on the vaccine platform, age, and sex examined. Importantly, the findings highlight that myocarditis occurs predominantly in male patients aged 12 to 40 years regardless of whether the cause was due to a virus-like SARS-CoV-2 or associated with a vaccine-a demographic that has been reported before COVID-19. This review discusses findings from COVID-19 and COVID-19 vaccine-associated myocarditis and pericarditis considering the known symptoms, diagnosis, management, treatment, and pathogenesis of disease that has been gleaned from clinical research and animal models. Sex differences in the immune response to COVID-19 are discussed, and theories for how mRNA vaccines could lead to myocarditis/pericarditis are proposed. Additionally, gaps in our understanding that need further research are raised.
Competing Interests: Disclosures D. Fairweather is on the advisory board of Cytokinetics. B. Heidecker is an inventor on patents that use RNA for diagnosis of myocarditis. L.T. Cooper has served as a consultant for myocarditis to Bristol Meyers Squibb, CardiolRx, Kiniksa, and Moderna. He has equity ownership in Stromal Therapeutics, Inc. The other authors report no conflicts.
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معلومات مُعتمدة: UL1 TR002556 United States TR NCATS NIH HHS; R21 AI154927 United States AI NIAID NIH HHS; R21 AI152318 United States AI NIAID NIH HHS; R21 AI145356 United States AI NIAID NIH HHS; R01 HL164520 United States HL NHLBI NIH HHS; TL1 TR002380 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: COVID-19 vaccines; mRNA vaccines; models, animal; sex characteristics; vaccines
المشرفين على المادة: 0 (COVID-19 Vaccines)
تواريخ الأحداث: Date Created: 20230511 Date Completed: 20230515 Latest Revision: 20240513
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC10171304
DOI: 10.1161/CIRCRESAHA.123.321878
PMID: 37167363
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4571
DOI:10.1161/CIRCRESAHA.123.321878