دورية أكاديمية
أعرض في EDS

Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP 3 R2 circuit.

التفاصيل البيبلوغرافية
العنوان: Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP 3 R2 circuit.
المؤلفون: Santana Nunez D; Department of Pharmacology and Regenerative Medicine, the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL, USA., Malik AB; Department of Pharmacology and Regenerative Medicine, the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL, USA., Lee Q; Department of Pharmacology and Regenerative Medicine, the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL, USA., Ahn SJ; Department of Medicine, University of Illinois College of Medicine, Chicago, IL, USA., Coctecon-Murillo A; Department of Pharmacology and Regenerative Medicine, the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL, USA., Lazarko D; Department of Medicine, University of Illinois College of Medicine, Chicago, IL, USA., Levitan I; Department of Medicine, University of Illinois College of Medicine, Chicago, IL, USA., Mehta D; Department of Pharmacology and Regenerative Medicine, the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL, USA., Komarova YA; Department of Pharmacology and Regenerative Medicine, the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL, USA.
المصدر: IScience [iScience] 2023 Apr 11; Vol. 26 (5), pp. 106661. Date of Electronic Publication: 2023 Apr 11 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: Endothelial cells (ECs) continuously sense and adapt to changes in shear stress generated by blood flow. Here, we show that the activation of the mechanosensitive channel Piezo1 by defined shear forces induces Ca 2+ entry into the endoplasmic reticulum (ER) via the ER Ca 2+ ATPase pump. This entry is followed by inositol trisphosphate receptor 2 (IP 3 R2)-elicited ER Ca 2+ release into the cytosol. The mechanism of ER Ca 2+ release involves the generation of cAMP by soluble adenylyl cyclase (sAC), leading to IP 3 R2-evoked Ca 2+ gating. Depleting sAC or IP 3 R2 prevents ER Ca 2+ release and blocks EC alignment in the direction of flow. Overexpression of constitutively active Akt1 restores the shear-induced alignment of ECs lacking Piezo1 or IP 3 R2, as well as the flow-induced vasodilation in endothelial restricted Piezo1 knockout mice. These studies describe an unknown Piezo1-cAMP-IP 3 R2 circuit as an essential mechanism activating Akt signaling and inducing adaptive changes in ECs to laminar flow.
Competing Interests: The authors have declared that no conflict of interest exists.
(© 2023 The Author(s).)
التعليقات: Erratum in: iScience. 2023 Dec 08;27(1):108633. doi: 10.1016/j.isci.2023.108633. (PMID: 38161411)
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معلومات مُعتمدة: R01 HL141120 United States HL NHLBI NIH HHS; R01 HL165263 United States HL NHLBI NIH HHS; T32 HL007829 United States HL NHLBI NIH HHS; R01 HL073965 United States HL NHLBI NIH HHS; R01 HL045638 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: cell biology; cellular physiology; molecular biology
تواريخ الأحداث: Date Created: 20230511 Latest Revision: 20240923
رمز التحديث: 20240923
مُعرف محوري في PubMed: PMC10164902
DOI: 10.1016/j.isci.2023.106661
PMID: 37168565
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2023.106661