دورية أكاديمية
Effect of Firocoxib and Flunixin Meglumine on Large Colon Mural Thickness of Healthy Horses.
| العنوان: | Effect of Firocoxib and Flunixin Meglumine on Large Colon Mural Thickness of Healthy Horses. |
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| المؤلفون: | Bishop RC; Department of Veterinary Clinical Medicine, University of Illinois, Urbana, Illinois. Electronic address: rb17@illinois.edu., Wilkins PA; Department of Veterinary Clinical Medicine, University of Illinois, Urbana, Illinois., Kemper AM; Department of Veterinary Clinical Medicine, University of Illinois, Urbana, Illinois., Stewart RM; Department of Veterinary Clinical Medicine, University of Illinois, Urbana, Illinois., McCoy AM; Department of Veterinary Clinical Medicine, University of Illinois, Urbana, Illinois. |
| المصدر: | Journal of equine veterinary science [J Equine Vet Sci] 2023 Jul; Vol. 126, pp. 104562. Date of Electronic Publication: 2023 May 11. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 8216840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0737-0806 (Print) Linking ISSN: 07370806 NLM ISO Abbreviation: J Equine Vet Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : New York : Elsevier Original Publication: [Wildomar, CA : William E. Jones, c1981- |
| مواضيع طبية MeSH: | Anti-Inflammatory Agents, Non-Steroidal*/adverse effects , Inflammation*/drug therapy , Inflammation*/veterinary, Humans ; Horses ; Animals ; Omeprazole/adverse effects ; Colon/diagnostic imaging |
| مستخلص: | Nonsteroidal anti-inflammatory drug (NSAID) administration carries risks of gastrointestinal toxicity. Selective COX-2 inhibitors ("coxibs") were designed to reduce risks of adverse effects but are still associated with gastrointestinal complications in humans. The effect of coxibs on colonic inflammation and integrity in horses is unknown. The study objective was to compare the effects of the coxib firocoxib and the nonselective NSAID flunixin meglumine on ultrasonographic indicators of colonic inflammation in healthy horses. Twelve healthy adult horses were administered flunixin meglumine (1.1 mg/kg IV q12h) and omeprazole (1 mg/kg PO q24h) for 5 days, allowed a 6-month washout period, then administered firocoxib (0.3 mg/kg PO once, then 0.1 mg/kg PO q24h for 4 days) and omeprazole. Transabdominal ultrasonographic examination and serum chemistry profiles were performed at the beginning and end of each treatment week. Colon wall thickness increased over time when horses received firocoxib (median post treatment 5.8 mm, interquartile range 2.8 mm; P < .001), but not flunixin (median 3 mm, interquartile range 1.2 mm; P = .7) and was significantly greater following firocoxib compared to flunixin (P = .003). Subjectively, colonic edema was noted more frequently following treatment with firocoxib (11/12 horses), compared to flunixin (1/12 horses). There were no clinically significant alterations in hematologic parameters after administration of either drug. The increase in colon wall thickness following treatment with the COX-2 selective NSAID firocoxib may suggest a risk of subclinical colitis in healthy horses. Monitoring colonic health when NSAIDs are used in a clinical setting is warranted. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: COX-2 selective inhibitor; Coxib; Equine; Nonsteroidal anti-inflammatory drug (NSAID); Subclinical colitis |
| المشرفين على المادة: | 8Y3JK0JW3U (flunixin meglumine) Y6V2W4S4WT (firocoxib) 0 (Anti-Inflammatory Agents, Non-Steroidal) KG60484QX9 (Omeprazole) |
| تواريخ الأحداث: | Date Created: 20230512 Date Completed: 20230626 Latest Revision: 20240313 |
| رمز التحديث: | 20240313 |
| DOI: | 10.1016/j.jevs.2023.104562 |
| PMID: | 37172749 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0737-0806 |
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| DOI: | 10.1016/j.jevs.2023.104562 |