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Orientin regulates the proliferation and migration of hepatocellular carcinoma cells.

التفاصيل البيبلوغرافية
العنوان: Orientin regulates the proliferation and migration of hepatocellular carcinoma cells.
المؤلفون: Tao JY; Department of Urology, Huanggang Central Hospital, Huanggang, China., Li J; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China., Wan L; Department of Department of Neurosurgery, Huanggang Central Hospital, Huanggang, China.; Huanggang Institute of Translational Medicine, Huanggang, China., Dong BZ; Huanggang Institute of Translational Medicine, Huanggang, China., Yu YJ; Huanggang Institute of Translational Medicine, Huanggang, China., Liu YM; Huanggang Institute of Translational Medicine, Huanggang, China., Yi ML; Surgery of Mammary Gland and Thyroid Gland, Huanggang Central Hospital, Huanggang, China. yimaolin@hgyy.org.cn., Wan LP; Department of Emergency Medicine, Huanggang Central Hospital, Huanggang, China. wanlipeng577666@sohu.com.
المصدر: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2023 Oct; Vol. 396 (10), pp. 2519-2528. Date of Electronic Publication: 2023 May 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer Verlag.
مواضيع طبية MeSH: Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/pathology, Humans ; NF-kappa B/metabolism ; Cell Proliferation ; Cell Line, Tumor
مستخلص: Orientin is a flavone isolated from medicinal plants used in traditional Chinese medicine (TCM) that suppresses the growth of cancer cells in vitro. The effects of orientin in hepatoma carcinoma cells remain unknown. The aim of this paper is to investigate the effects of orientin on the viability, proliferation, and migration of hepatocellular carcinoma cells in vitro. In this study, we found that orientin could inhibit the proliferation, migration, and the activation of NF-κB signaling pathway in hepatocellular carcinoma cells. An activator of NF-κB signaling pathway, PMA, could abolish the inhibitory effect of orientin on NF-κB signaling pathway and proliferation and migration of Huh7 cells. These findings raise the possibility that orientin can be used in the treatment of hepatocellular carcinoma.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة: Keywords: HCC; HepG2; Huh7; NF-κB; Orientin
المشرفين على المادة: IAX93XCW6C (orientin)
0 (NF-kappa B)
تواريخ الأحداث: Date Created: 20230513 Date Completed: 20230913 Latest Revision: 20230922
رمز التحديث: 20231215
DOI: 10.1007/s00210-023-02472-y
PMID: 37178274
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1912
DOI:10.1007/s00210-023-02472-y