دورية أكاديمية
Time to Virological Failure and Its Predictor Among HIV-Positive Clients with the Differentiated Service Delivery Model of HIV at Debre Berhan Comprehensive Specialized Hospital, Amhara Regional State, Ethiopia, 2021: A Retrospective Cohort Study.
| العنوان: | Time to Virological Failure and Its Predictor Among HIV-Positive Clients with the Differentiated Service Delivery Model of HIV at Debre Berhan Comprehensive Specialized Hospital, Amhara Regional State, Ethiopia, 2021: A Retrospective Cohort Study. |
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| المؤلفون: | Mekuria AD; Department of Public Health, Asrate Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia., Meseret WA; Department of Public Health, Asrate Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia., Assefa HK; Department of Nursing, Asrate Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia., Sisay AL; Department of Epidemiology and Bio-Statistics, Public Health Faculty Institute of Health Science, Jimma University, Jimma, Ethiopia., Bilchut AH; Department of Public Health, Asrate Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia., Derseh BT; Department of Public Health, Asrate Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia., Abebe AM; Department of Nursing, Asrate Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia., Tesfahun E; Department of Public Health, Asrate Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia., Minda A; Department of Public Health, Asrate Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia., Equbay M; Department of Public Health, Asrate Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia. |
| المصدر: | AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2023 Oct; Vol. 39 (10), pp. 547-557. Date of Electronic Publication: 2023 Jun 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8709376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-8405 (Electronic) Linking ISSN: 08892229 NLM ISO Abbreviation: AIDS Res Hum Retroviruses Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: [New York] : Mary Ann Liebert, [c1987- |
| مستخلص: | Diversified antiretroviral therapy (ART) approach is needed in methods that were acceptable to communities and maintain good viral suppression outcomes to reach the UNAIDS targets to end the HIV/AIDS epidemic by 2030. Ethiopia is fully implementing differentiated service delivery (DSD) approaches, appointment spacing, and standard care. This study aimed to determine the time to HIV virological failure and its predictors among patients with a DSD model. An institution-based retrospective cohort study was conducted with data collection dates ranging from May 1, 2021, to May 30, 2021. All adult HIV-positive patients ( n = 2,148) between January 2018 and January 2021 were a source population. Data were extracted using a standard checklist by trained data collectors and entered into EpiData, exported to SPSS version 20 for data management, and then exported to R Studio version 1.4 for analysis. Kaplan-Meier survival curves, the log-rank test, and Cox proportional hazard regression models were employed. The incidence of virological failure was 86 per 10,000 person-months. The independent predictors for the hazard of virological failure were being on standard care [adjusted hazard ratios (AHR) = 1.91; 95% confidence interval (CI) 1.07-3.40], primarily educated (AHR = 3.46; 95% CI 1.02-11.72), having no education (AHR = 3.45; 95% CI 1.01-11.85), and ambulatory status at baseline (AHR = 1.81; 95% CI 1.06-3.09). Patients who had a viral load with a detectable range from 50 to 999 at engagement (AHR = 2.65; 95% CI 1.33-5.27) and a 1-month increase in ART for HIV patients (AHR = 1.045; 95% CI 1.01-1.09). The incidence of virological failure was 86 per 10,000 person-months, whereas the incidences were 52 per 10,000 person-months and 71 per 10,000 person-months on appointment spacing model and standard care, respectively, with independent predictors: patient category, educational status, baseline functional status, viral load at engagement, and duration of ART. |
| فهرسة مساهمة: | Keywords: Ethiopia; HIV/AIDS; UNAIDS; appointment spacing; differentiated care; treatment failure |
| تواريخ الأحداث: | Date Created: 20230515 Latest Revision: 20231010 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1089/AID.2022.0153 |
| PMID: | 37183404 |
| قاعدة البيانات: | MEDLINE |
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