Image registration and mutual thresholding enable low interimage variability across dynamic MRI measurements of supraclavicular brown adipose tissue during mild cold exposure.

التفاصيل البيبلوغرافية
العنوان:	Image registration and mutual thresholding enable low interimage variability across dynamic MRI measurements of supraclavicular brown adipose tissue during mild cold exposure.
المؤلفون:	Sardjoe Mishre ASD; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Radiology, C.J. Gorter MRI Center, Leiden University Medical Center, Leiden, the Netherlands., Martinez-Tellez B; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands., Straat ME; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands., Boon MR; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands., Dzyubachyk O; Department of Radiology, Division of Image Processing, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cell and Chemical Biology, Electron Microscopy Section, Leiden University Medical Center, Leiden, the Netherlands., Webb AG; Department of Radiology, C.J. Gorter MRI Center, Leiden University Medical Center, Leiden, the Netherlands., Rensen PCN; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands., Kan HE; Department of Radiology, C.J. Gorter MRI Center, Leiden University Medical Center, Leiden, the Netherlands.
المصدر:	Magnetic resonance in medicine [Magn Reson Med] 2023 Oct; Vol. 90 (4), pp. 1316-1327. Date of Electronic Publication: 2023 May 15.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Wiley Country of Publication: United States NLM ID: 8505245 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-2594 (Electronic) Linking ISSN: 07403194 NLM ISO Abbreviation: Magn Reson Med Subsets: MEDLINE
أسماء مطبوعة:	Publication: 1999- : New York, NY : Wiley Original Publication: San Diego : Academic Press,
مواضيع طبية MeSH:	Adipose Tissue, Brown/diagnostic imaging , Adipose Tissue, Brown/metabolism , Magnetic Resonance Imaging*/methods, Humans ; Young Adult ; Adult
مستخلص:	Purpose: Activated brown adipose tissue (BAT) enhances lipid catabolism and improves cardiometabolic health. Quantitative MRI of the fat fraction (FF) of supraclavicular BAT (scBAT) is a promising noninvasive measure to assess BAT activity but suffers from high scan variability. We aimed to test the effects of coregistration and mutual thresholding on the scan variability in a fast (1 min) time-resolution MRI protocol for assessing scBAT FF changes during cold exposure. Methods: Ten volunteers (age 24.8 ± 3.0 years; body mass index 21.2 ± 2.1 kg/m ² ) were scanned during thermoneutrality (32°C; 10 min) and mild cold exposure (18°C; 60 min) using a 12-point gradient-echo sequence (70 consecutive scans with breath-holds, 1.03 min per dynamic). Dynamics were coregistered to the first thermoneutral scan, which enabled drawing of single regions of interest in the scBAT depot. Voxel-wise FF changes were calculated at each time point and averaged across regions of interest. We applied mutual FF thresholding, in which voxels were included if their FF was greater than 30% FF in the reference scan and the registered dynamic. The efficacy of the coregistration was determined by using a moving average and comparing the mean squared error of residuals between registered and nonregistered data. Registered scBAT ΔFF was compared with single-scan thresholding using the moving average method. Results: Registered scBAT ΔFF had lower mean square error values than nonregistered data (0.07 ± 0.05% vs. 0.16 ± 0.14%; p < 0.05), and mutual thresholding reduced the scBAT ΔFF variability by 30%. Conclusion: We demonstrate that coregistration and mutual thresholding improve stability of the data 2-fold, enabling assessment of small changes in FF following cold exposure. (© 2023 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
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فهرسة مساهمة:	Keywords: brown adipose tissue; cold exposure; fat fraction; magnetic resonance imaging
تواريخ الأحداث:	Date Created: 20230515 Date Completed: 20230731 Latest Revision: 20230801
رمز التحديث:	20230801
DOI:	10.1002/mrm.29707
PMID:	37183785
قاعدة البيانات:	MEDLINE

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تدمد:	1522-2594
DOI:	10.1002/mrm.29707