دورية أكاديمية
Identification of Potential Therapeutic Targets on the Level of DNA/mRNAs, Proteins and Metabolites: A Systematic Mapping Review of Scientific Texts' Fragments from Open Targets.
| العنوان: | Identification of Potential Therapeutic Targets on the Level of DNA/mRNAs, Proteins and Metabolites: A Systematic Mapping Review of Scientific Texts' Fragments from Open Targets. |
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| المؤلفون: | Pogodin PV; Institute of Biomedical Chemistry, Pogodinskaya Street, 10, 119121 Moscow, Russia., Kiseleva OI; Institute of Biomedical Chemistry, Pogodinskaya Street, 10, 119121 Moscow, Russia., Ilgisonis EV; Institute of Biomedical Chemistry, Pogodinskaya Street, 10, 119121 Moscow, Russia. |
| المصدر: | Current issues in molecular biology [Curr Issues Mol Biol] 2023 Apr 13; Vol. 45 (4), pp. 3406-3418. Date of Electronic Publication: 2023 Apr 13. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100931761 Publication Model: Electronic Cited Medium: Internet ISSN: 1467-3045 (Electronic) Linking ISSN: 14673037 NLM ISO Abbreviation: Curr Issues Mol Biol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Basel, Switzerland : MDPI Original Publication: Wymondham, Norfolk, UK : Caister Academic Press, |
| مستخلص: | Database records contain useful information, which is readily available, but, unfortunately, limited compared to the source (publications). Our study reviewed the text fragments supporting the association between the biological macromolecules and diseases from Open Targets to map them on the biological level of study (DNA/RNA, proteins, metabolites). We screened records using a dictionary containing terms related to the selected levels of study, reviewed 600 hits manually and used machine learning to classify 31,260 text fragments. Our results indicate that association studies between diseases and macromolecules conducted on the level of DNA and RNA prevail, followed by the studies on the level of proteins and metabolites. We conclude that there is a clear need to translate the knowledge from the DNA/RNA level to the evidence on the level of proteins and metabolites. Since genes and their transcripts rarely act in the cell by themselves, more direct evidence may be of greater value for basic and applied research. |
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| معلومات مُعتمدة: | 122030100170-5 The work was performed within the framework of the Program for Basic Research in the Russian Federation for a long-term period (2021 - 2030) |
| فهرسة مساهمة: | Keywords: DNA and RNA; machine learning; metabolites; proteins; text analysis; textual evidence of a target-disease association; therapeutic targets discovery |
| تواريخ الأحداث: | Date Created: 20230515 Latest Revision: 20230517 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC10137072 |
| DOI: | 10.3390/cimb45040223 |
| PMID: | 37185747 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1467-3045 |
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| DOI: | 10.3390/cimb45040223 |