دورية أكاديمية
أعرض في EDS

Establishment of Skeletal Myogenic Progenitors from Non-Human Primate Induced Pluripotent Stem Cells.

التفاصيل البيبلوغرافية
العنوان: Establishment of Skeletal Myogenic Progenitors from Non-Human Primate Induced Pluripotent Stem Cells.
المؤلفون: Baik J; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA., Ortiz-Cordero C; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA., Magli A; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA., Azzag K; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA., Crist SB; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA., Yamashita A; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA., Kiley J; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA., Selvaraj S; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA., Mondragon-Gonzalez R; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA., Perrin E; Stem Cell Resources and the Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA., Maufort JP; Stem Cell Resources and the Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA., Janecek JL; Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA., Lee RM; Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA., Stone LH; Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA., Rangarajan P; Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA., Ramachandran S; Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA., Graham ML; Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA., Perlingeiro RCR; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
المصدر: Cells [Cells] 2023 Apr 13; Vol. 12 (8). Date of Electronic Publication: 2023 Apr 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Induced Pluripotent Stem Cells*/metabolism , Pluripotent Stem Cells*/metabolism, Animals ; Mice ; Tissue Distribution ; Muscle, Skeletal/metabolism ; Primates ; Pentosyltransferases/metabolism
مستخلص: Pluripotent stem (PS) cells enable the scalable production of tissue-specific derivatives with therapeutic potential for various clinical applications, including muscular dystrophies. Given the similarity to human counterparts, the non-human primate (NHP) is an ideal preclinical model to evaluate several questions, including delivery, biodistribution, and immune response. While the generation of human-induced PS (iPS)-cell-derived myogenic progenitors is well established, there have been no data for NHP counterparts, probably due to the lack of an efficient system to differentiate NHP iPS cells towards the skeletal muscle lineage. Here, we report the generation of three independent Macaca fascicularis iPS cell lines and their myogenic differentiation using PAX7 conditional expression. The whole-transcriptome analysis confirmed the successful sequential induction of mesoderm, paraxial mesoderm, and myogenic lineages. NHP myogenic progenitors efficiently gave rise to myotubes under appropriate in vitro differentiation conditions and engrafted in vivo into the TA muscles of NSG and FKRP-NSG mice. Lastly, we explored the preclinical potential of these NHP myogenic progenitors in a single wild-type NHP recipient, demonstrating engraftment and characterizing the interaction with the host immune response. These studies establish an NHP model system through which iPS-cell-derived myogenic progenitors can be studied.
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معلومات مُعتمدة: T32 HL144472 United States HL NHLBI NIH HHS; R01AR078571 United States AR NIAMS NIH HHS; R01 AR078571 United States AR NIAMS NIH HHS; R01AR078624 United States AR NIAMS NIH HHS; R01 AR078624 United States AR NIAMS NIH HHS; UL1 TR002494 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: RNA sequencing; induced pluripotent stem cells; muscle regeneration; muscular dystrophy; myogenesis; non-human primate; stem cell therapy
المشرفين على المادة: EC 2.4.2.- (Fkrp protein, mouse)
EC 2.4.2.- (Pentosyltransferases)
تواريخ الأحداث: Date Created: 20230516 Date Completed: 20230517 Latest Revision: 20240603
رمز التحديث: 20240603
مُعرف محوري في PubMed: PMC10137227
DOI: 10.3390/cells12081147
PMID: 37190056
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells12081147