دورية أكاديمية
Sex disparity in stroke outcomes in a multicenter prospective stroke registry in Vietnam.
| العنوان: | Sex disparity in stroke outcomes in a multicenter prospective stroke registry in Vietnam. |
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| المؤلفون: | Ton MD; Department of Neurology, Faculty of Stroke and Cerebrovascular Disease, Faculty of Stroke and Cerebrovascular Disease, University of Medicine & Pharmacy, Vietnam National University, Hanoi, Vietnam.; Stroke Center, Center of Neurology, Bach Mai Hospital, Hanoi, Vietnam.; Hanoi Medical University, Hanoi, Vietnam., Dao PV; Department of Neurology, Faculty of Stroke and Cerebrovascular Disease, Faculty of Stroke and Cerebrovascular Disease, University of Medicine & Pharmacy, Vietnam National University, Hanoi, Vietnam.; Stroke Center, Center of Neurology, Bach Mai Hospital, Hanoi, Vietnam.; Hanoi Medical University, Hanoi, Vietnam., Nguyen DT; Department of Neurology, Faculty of Stroke and Cerebrovascular Disease, Faculty of Stroke and Cerebrovascular Disease, University of Medicine & Pharmacy, Vietnam National University, Hanoi, Vietnam.; Stroke Center, Center of Neurology, Bach Mai Hospital, Hanoi, Vietnam., Nguyen TH; Cerebrovascular Disease Department, People's Hospital 115, Ho Chi Minh City, Vietnam., Tran CC; Stroke International Services (SIS) General Hospital, Can Tho, Vietnam., Duong HQ; Da Nang Hospital, Da Nang, Vietnam., Nguyen HN; Nghe An Friendship General Hospital, Vinh, Vietnam., Nguyen SH; Thanh Hoa General Hospital, Thanh Hoa, Vietnam., Bui HT; Thai Nguyen National Hospital, Thai Nguyen, Vietnam., Dang DP; Military Medical Academy, Hanoi, Vietnam., Dao NT; Ninh Binh General Hospital, Ninh Binh, Vietnam., Bui HTT; Phu Tho General Hospital, Phu Tho City, Vietnam., Hoang HB; Hanoi Medical University, Hanoi, Vietnam.; Hanoi Medical University Hospital, Hanoi, Vietnam., Vo KH; Department of Neurology, Faculty of Stroke and Cerebrovascular Disease, Faculty of Stroke and Cerebrovascular Disease, University of Medicine & Pharmacy, Vietnam National University, Hanoi, Vietnam.; Stroke Center, Center of Neurology, Bach Mai Hospital, Hanoi, Vietnam.; Hanoi Medical University, Hanoi, Vietnam., Nguyen CD; Hanoi Heart Hospital, Hanoi, Vietnam., Pham TQ; Stroke Center, Center of Neurology, Bach Mai Hospital, Hanoi, Vietnam., Nguyen TN; Departments of Neurology and Radiology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. |
| المصدر: | International journal of stroke : official journal of the International Stroke Society [Int J Stroke] 2023 Oct; Vol. 18 (9), pp. 1102-1111. Date of Electronic Publication: 2023 Jun 01. |
| نوع المنشور: | Review; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 101274068 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4949 (Electronic) Linking ISSN: 17474930 NLM ISO Abbreviation: Int J Stroke Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Thousand Oaks, CA : SAGE Publications Original Publication: Oxford, UK : Blackwell Pub., c2005- |
| مواضيع طبية MeSH: | Stroke*/epidemiology , Stroke*/therapy , Stroke*/complications , Ischemic Stroke*/complications , Hemorrhagic Stroke*/complications , Brain Ischemia*/epidemiology , Brain Ischemia*/therapy , Brain Ischemia*/complications , Atherosclerosis*, Humans ; Female ; Male ; Middle Aged ; Vietnam/epidemiology ; Treatment Outcome ; Registries ; Multicenter Studies as Topic |
| مستخلص: | Background: Although men have a higher rate of stroke than women, it is not clear whether women have a worse outcome after adjusting for confounders such as vascular risk factors, age, stroke severity, and reperfusion therapy. We evaluated sex differences on 90-day functional outcomes after stroke in a multicenter study in Vietnam. Methods: We recruited patients presenting with ischemic or hemorrhagic stroke at 10 stroke centers in Vietnam for a period of 1 month from 1 August 2022 to 31 August 2022. We reviewed the patient's clinical demographics, time from symptom onset to hospital admission, stroke classification, stroke subtype, stroke severity, characteristics of reperfusion therapy, and 90-day clinical outcome. We compared functional outcomes and predisposing factors at day 90 between men and women after an ischemic and hemorrhagic stroke. Poor outcome was defined as modified Rankin Scale 3-6. Results: There were 2300 stroke patients included. Men accounted for 61.3% (1410) of participants. Compared to men, women were older (67.7 ± 13.9 vs 63.7 ± 13.3, P < 0.001), had a higher rate of diabetes mellitus (21.1% vs 15.3%, P < 0.001), a lower rate of tobacco use (1.0 % vs 23.6%, P < 0.001), and a lower body mass index (21.4 ± 2.70 vs 22.0 ± 2.72, P < 0.001). There was a higher rate of intracranial hemorrhage (ICH) in men (21.3% vs 15.6%, P = 0.001), whereas the rate of subarachnoid hemorrhage was higher in women (6.2% vs 3.0%, P < 0.001). For ischemic stroke, door-to-needle time (36.9 ± 17.6 vs 47.8 ± 35.2 min, P = 0.04) and door-to-recanalization time (113.6 ± 51.1 vs 134.2 ± 48.2, P = 0.03) were shorter in women. There was no difference in 90-day functional outcomes between sexes. Factors associated with poor outcomes included age ⩾50 years (adjusted odds ratio (aOR): 1.75; 95% confidence interval (CI): 1.16-2.66), history of stroke (aOR: 1.50; 95% CI: 1.15-1.96), large artery atherosclerosis (aOR: 5.19; 95% CI: 3.90-6.90), and cardioembolism (aOR: 3.21; 95% CI: 1.68-6.16). Factors associated with mortality in patients with acute ischemic stroke included a history of coronary artery disease (aOR: 3.04; 95% CI: 1.03-8.92), large artery atherosclerosis (aOR: 3.37; 95% CI: 2.11-5.37), and cardioembolism (aOR: 3.15; 95% CI: 1.20-8.27). Conclusion: There were no sex differences in the clinical outcome of stroke and ischemic stroke in this prospective cohort of hospitalized Vietnamese patients. Competing Interests: Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: T. Nguyen discloses research support from Medtronic, Society of Vascular and Interventional Neurology (SVIN) and advisory board from Idorsia (unrelated). |
| فهرسة مساهمة: | Keywords: Stroke; factor; intracranial hemorrhage; ischemic stroke; outcome; sex |
| تواريخ الأحداث: | Date Created: 20230516 Date Completed: 20231030 Latest Revision: 20231030 |
| رمز التحديث: | 20231030 |
| DOI: | 10.1177/17474930231177893 |
| PMID: | 37190749 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1747-4949 |
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| DOI: | 10.1177/17474930231177893 |