دورية أكاديمية
أعرض في EDS

Changes in Vaginal Bacteria and Inflammatory Mediators From Periconception Through the Early Postpartum Period in a Cohort of Kenyan Women Without HIV.

التفاصيل البيبلوغرافية
العنوان: Changes in Vaginal Bacteria and Inflammatory Mediators From Periconception Through the Early Postpartum Period in a Cohort of Kenyan Women Without HIV.
المؤلفون: Sabo MC; Department of Medicine, University of Washington, Seattle, Washington, USA., Lokken EM; Department of Global Health, University of Washington, Seattle, Washington, USA., Srinivasan S; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Kinuthia J; Department of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.; Institute of Tropical and Infectious Diseases, University of Nairobi, Nairobi, Kenya., Richardson BA; Department of Global Health, University of Washington, Seattle, Washington, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Fiedler TL; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Munch M; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Proll S; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Salano C; Department of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.; Institute of Tropical and Infectious Diseases, University of Nairobi, Nairobi, Kenya., John-Stewart G; Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Pediatrics, University of Washington, Seattle, Washington, USA., Jaoko W; Department of Medical Microbiology and Immunology, University of Nairobi, Nairobi, Kenya., Fredricks DN; Department of Medicine, University of Washington, Seattle, Washington, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., McClelland RS; Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Medical Microbiology and Immunology, University of Nairobi, Nairobi, Kenya.
المصدر: The Journal of infectious diseases [J Infect Dis] 2023 Aug 16; Vol. 228 (4), pp. 487-499.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
مواضيع طبية MeSH: Inflammation Mediators* , HIV Infections*/complications, Pregnancy ; Female ; Humans ; Kenya/epidemiology ; Ligands ; Vagina/microbiology ; Bacteria ; Postpartum Period ; Cytokines ; RNA, Ribosomal, 16S/genetics
مستخلص: Background: Women's increased risk of HIV acquisition during pregnancy and postpartum may be mediated by changes in vaginal microbiota and/or cytokines.
Methods: A cohort of 80 Kenyan women who were HIV-1 seronegative contributed 409 vaginal samples at 6 pregnancy time points: periconception, positive pregnancy test result, first trimester, second trimester, third trimester, and postpartum. Concentrations of vaginal bacteria linked with HIV risk and Lactobacillus spp were measured using quantitative polymerase chain reaction. Cytokines were measured by immunoassay.
Results: Based on Tobit regression, later pregnancy time points were associated with lower concentrations of Sneathia spp (P = .01), Eggerthella sp type 1 (P = .002), and Parvimonas sp type 2 (P = .02) and higher concentrations of Lactobacillus iners (P < .001), Lactobacillus crispatus (P < .001), Lactobacillus vaginalis (P < .001), interleukin 6 (P < .001), TNF (P = .004), C-X-C motif chemokine ligand 10 (CXCL10; P < .001), C-C motif ligand 3 (P = .009), C-C motif ligand 4 (P < .001), C-C motif ligand 5 (P = .002), interleukin 1β (P = .02), and interleukin 8 (P = .002). Most cervicovaginal cytokines and vaginal bacteria clustered separately in principal component analysis, except for CXCL10, which did not group with either cytokines or bacteria. The shift toward a Lactobacillus-dominated microbiota during pregnancy mediated the relationship between pregnancy time point and CXCL10.
Conclusions: Increases in proinflammatory cytokines, but not vaginal bacterial taxa linked with higher HIV risk, could provide an explanation for increased HIV susceptibility during pregnancy and postpartum.
Competing Interests: Potential conflicts of interest. R. S. M. receives research funding, paid to the University of Washington, from Hologic Corporation. B. A. R. receives honoraria from Gilead for serving on data safety monitoring boards. D. N. F. and T. L. F. receive a royalty from BD. S. S. has received speaking honoraria from Lupin Pharmaceuticals. E. M. L.'s contributions to this study primarily occurred while affiliated with the University of Washington; at the time of submission, E. M. L. was an employee of AbbVie and holds stock or stock grants. All other authors report no potential conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
(© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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معلومات مُعتمدة: K23 HD100221 United States HD NICHD NIH HHS; K24 HD088229 United States HD NICHD NIH HHS; F32 HD100202 United States HD NICHD NIH HHS; R01 HD087346 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: HIV-risk; cervicovaginal cytokines; postpartum; pregnancy; vaginal microbiota
المشرفين على المادة: 0 (Inflammation Mediators)
0 (Ligands)
0 (Cytokines)
0 (RNA, Ribosomal, 16S)
تواريخ الأحداث: Date Created: 20230519 Date Completed: 20230817 Latest Revision: 20240520
رمز التحديث: 20240520
مُعرف محوري في PubMed: PMC10428199
DOI: 10.1093/infdis/jiad168
PMID: 37207618
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-6613
DOI:10.1093/infdis/jiad168