دورية أكاديمية
Pioneering in vitro characterization of macrophage response induced by scorpion venoms from the Brazilian Amazon.
| العنوان: | Pioneering in vitro characterization of macrophage response induced by scorpion venoms from the Brazilian Amazon. |
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| المؤلفون: | Reis MB; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil; School of Medicine, Centro Universitário Barão de Mauá (CBM), Ribeirão Preto, SP, Brazil., Martins JG; Graduate Program in Genetics, Conservation and Evolutionary Biology (PPG GCBEv), National Institute for Amazon Research (INPA), Manaus, AM, Brazil., Bordon KCF; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil., de Campos Fraga-Silva TF; Program of Basic and Applied Immunology, And Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil., de Lima Procópio RE; Graduate Program in Biotechnology and Natural Resources of Amazon, University of the State of Amazonas (UEA), Manaus, AM, Brazil., de Almeida BRR; Instituto Federal de Educação, Ciência e Tecnologia Do Pará, Campus Itaituba, Pará, Brazil., Bonato VLD; Program of Basic and Applied Immunology, And Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil., Arantes EC; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil. Electronic address: ecabraga@fcfrp.usp.br. |
| المصدر: | Toxicon : official journal of the International Society on Toxinology [Toxicon] 2023 Jul; Vol. 230, pp. 107171. Date of Electronic Publication: 2023 May 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1962- |
| مواضيع طبية MeSH: | Scorpion Venoms*/toxicity , Scorpion Stings*, Humans ; Mice ; Animals ; Brazil ; Scorpions ; Macrophages |
| مستخلص: | There are several scorpion species of medical relevance around the world. Some of them are well characterized by their toxins and clinical outcomes. Brazilian Amazon has a great amount of these arthropods that have an impact in the scorpionism events specifically in this region of Brazil. Recently, several studies pointed out the immune system activation during scorpion envenouming as an important facet of scorpionism, inducing a sepsis-like state that culminates in clinical severity and death. In this work, we characterized the macrophage response of three species of clinical relevance in Brazilian Amazon: Tityus silvestris, T. metuendus and T. obscurus and one specie with no toxic effects to humans, Brotheas amazonicus. All the four species analyzed were able to induce pro- and anti-inflammatory cytokine production in a J774.1 murine macrophage model. This activation was dependent on TLR2/TLR4/MyD88 activation and abolished by TLRs antagonists. These results suggest that the venoms of the four species analyzed were able to induce macrophage response in agreement to the well-established immune activation by T. serrulatus venom. Our findings provide new insights into the clinical repercussions of scorpionism of uncharacterized species and point to new biotechnological applications of these venoms and possible supportive therapies in scorpionism. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Brotheas amazonicus; Tityus metuendus; Tityus obscurus, macrophage; Tityus silvestris |
| المشرفين على المادة: | 0 (Scorpion Venoms) |
| تواريخ الأحداث: | Date Created: 20230521 Date Completed: 20230614 Latest Revision: 20230614 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.toxicon.2023.107171 |
| PMID: | 37211059 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3150 |
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| DOI: | 10.1016/j.toxicon.2023.107171 |