دورية أكاديمية
Transcatheter Left Atrial Appendage Closure.
| العنوان: | Transcatheter Left Atrial Appendage Closure. |
|---|---|
| المؤلفون: | Wong GX; University of California, Davis Medical Center, Sacramento, California, US., Singh GD; University of California, Davis Medical Center, Sacramento, California, US. |
| المصدر: | Methodist DeBakey cardiovascular journal [Methodist Debakey Cardiovasc J] 2023 May 16; Vol. 19 (3), pp. 67-77. Date of Electronic Publication: 2023 May 16 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Methodist DeBakey Heart & Vascular Center Country of Publication: United States NLM ID: 101508600 Publication Model: eCollection Cited Medium: Internet ISSN: 1947-6108 (Electronic) Linking ISSN: 19476108 NLM ISO Abbreviation: Methodist Debakey Cardiovasc J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Houston, TX : Methodist DeBakey Heart & Vascular Center |
| مواضيع طبية MeSH: | Atrial Fibrillation*/complications , Atrial Fibrillation*/diagnosis , Atrial Fibrillation*/therapy , Atrial Appendage*/diagnostic imaging , Stroke*/etiology , Stroke*/prevention & control, Humans ; Treatment Outcome ; Anticoagulants/adverse effects |
| مستخلص: | Atrial fibrillation is the most common arrhythmia worldwide, placing a large population at risk for potentially disabling ischemic strokes, yet an estimated 50% of eligible patients cannot tolerate or are contraindicated to receive oral anticoagulation. Within the last 15 years, transcatheter options for left atrial appendage closure (LAAC) have provided a valuable alternative to chronic oral anticoagulation for reducing risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. With newer generation devices such as Watchman FLX and Amulet gaining approval from the US Food and Drug Administration in recent years, several large clinical trials have demonstrated the safety and efficacy of transcatheter LAAC in a population intolerant to systemic anticoagulation. In this contemporary review, we discuss the indications for transcatheter LAAC and the evidence evaluating the use of various device therapies currently available or in development. We also examine current unmet challenges in intraprocedural imaging and controversies in postimplantation antithrombotic regimens. Several ongoing seminal trials are hoping to clarify the role of transcatheter LAAC as a safe, first-line option for all patients with nonvalvular atrial fibrillation. Competing Interests: Dr. Gagan D Singh is a consultant and/or an Advisory Board member for Abbott Structural Heart, Boston Scientific, Siemens Healthcare, and Phillips. Dr. Wong has no competing interests to declare. (Copyright: © 2023 The Author(s).) |
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| فهرسة مساهمة: | Keywords: anticoagulation intolerance; atrial fibrillation; dual antiplatelet therapy; intracardiac echocardiography; left atrial appendage occlusion; percutaneous left atrial appendage closure |
| المشرفين على المادة: | 0 (Anticoagulants) |
| تواريخ الأحداث: | Date Created: 20230522 Date Completed: 20230524 Latest Revision: 20240918 |
| رمز التحديث: | 20240918 |
| مُعرف محوري في PubMed: | PMC10198237 |
| DOI: | 10.14797/mdcvj.1215 |
| PMID: | 37213882 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1947-6108 |
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| DOI: | 10.14797/mdcvj.1215 |