دورية أكاديمية
أعرض في EDS

Investigation of interest in and timing preference for cancer predisposition testing and expanded carrier screening among women of reproductive age.

التفاصيل البيبلوغرافية
العنوان: Investigation of interest in and timing preference for cancer predisposition testing and expanded carrier screening among women of reproductive age.
المؤلفون: Zhong L; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States.; Department of Communication, University of Utah, Salt Lake City, UT, United States., Bather JR; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States., Daly BM; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States., Kohlmann WK; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States., Goodman MS; Department of Biostatistics, New York University School of Global Public Health, New York City, NY, United States., Rothwell E; Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA., Kaphingst KA; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States.; Department of Communication, University of Utah, Salt Lake City, UT, United States.
المصدر: PEC innovation [PEC Innov] 2023 Jan 24; Vol. 2, pp. 100128. Date of Electronic Publication: 2023 Jan 24 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918367980406676 Publication Model: eCollection Cited Medium: Internet ISSN: 2772-6282 (Electronic) Linking ISSN: 27726282 NLM ISO Abbreviation: PEC Innov Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier B.V., [2022]-
مستخلص: Objective: To examine cognitive, relational, and social predictors of interest in and timing preference for cancer predisposition testing (CPT) and expanded carrier screening (ECS) offered in routine gynecologic care for women of reproductive age.
Methods: Women between 20 and 35 years old who were currently pregnant or had a prior pregnancy ( N = 351) completed an online survey. Bivariate and multivariable analyses were used to identify significant predictors of women's interest in and timing preference for CPT and ECS.
Results: Most respondents reported high interest in CPT and ECS and preferred to have them when planning for a pregnancy. Perceived importance of genetic information and negative attitude towards uncertainty predicted interest in CPT and ECS in multivariable models. Genetic knowledge predicted preference for CPT or ECS when planning for a pregnancy.
Conclusion: Educational and decision support tools should be developed to enhance women's knowledge and awareness of CPT and ECS and to provide them with strategies to manage uncertainty.
Innovation: We examined women's timing preference for CPT and ECS and the impact of partner support and trust with gynecologist. A context-specific attitudes toward uncertainty scale was used to investigate women's particular perceptions of uncertainty in genetic testing.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 The Authors.)
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معلومات مُعتمدة: RM1 HG009037 United States HG NHGRI NIH HHS
فهرسة مساهمة: Keywords: Cancer predisposition testing; Expanded carrier screening; Interest; Pregnancy; Timing preference
تواريخ الأحداث: Date Created: 20230522 Latest Revision: 20240330
رمز التحديث: 20240330
مُعرف محوري في PubMed: PMC10194195
DOI: 10.1016/j.pecinn.2023.100128
PMID: 37214524
قاعدة البيانات: MEDLINE
الوصف
تدمد:2772-6282
DOI:10.1016/j.pecinn.2023.100128