دورية أكاديمية
أعرض في EDS

The influence of smoking on oral neutrophils and matrix metalloproteinase-8 in periodontitis patients before and after nonsurgical treatment.

التفاصيل البيبلوغرافية
العنوان: The influence of smoking on oral neutrophils and matrix metalloproteinase-8 in periodontitis patients before and after nonsurgical treatment.
المؤلفون: Do HT; Department of Periodontology, Faculty of Odonto-stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam., Nguyen TT; Department of Periodontology, Faculty of Odonto-stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam., Vo TL; Department of Implantology, Faculty of Odonto-stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam., Huynh NC; Department of Dental Basic Sciences, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam., Nguyen ATK; Department of Dental Basic Sciences, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam.
المصدر: Journal of oral biology and craniofacial research [J Oral Biol Craniofac Res] 2023 May-Jun; Vol. 13 (3), pp. 442-447. Date of Electronic Publication: 2023 May 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101619156 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2212-4268 (Print) Linking ISSN: 22124268 NLM ISO Abbreviation: J Oral Biol Craniofac Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier, 2011-
مستخلص: Objective: To evaluate and compare the oral neutrophil numbers (ONN) in saliva, the level of matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF) and the periodontal parameters in smokers versus non-smokers with periodontitis, before and after nonsurgical periodontal treatment (NSPT).
Materials and Method: 40 chronic periodontitis patients including 20 smokers and 20 non-smokers were enrolled in this quasi-experimental study. All patients were received the NSPT included instructing oral hygiene, scaling and root planing. At baseline (T0) and after NSPT 1 month (T1) and 3 months (T3), all patients were assessed for salivary ONN, GCF MMP-8, and clinical parameters like plaque index (PlI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment loss (CAL). The differences between the two groups were analyzed using the independent sample t -test and the Mann-Whitney U test; and the differences between T0, T1 and T3 of each group were analyzed with paired-samples t -test and Wilcoxon signed-rank test. The level of significance was set at 0.05.
Results: The ONN was significantly less in smokers than in non-smokers although there was no significant difference in other parameters between the two groups at baseline (p > 0.05). All clinical periodontal parameters reduced significantly after 1 month and 3 months of NSPT in both groups (p < 0.01). PPD of non-smokers was significantly lower than those of smokers at T1 and T3. ONN and MMP-8 level showed a significant decrease in non-smoking subjects, while there was no significant difference in smoking ones after NSPT (T1 and T3). At 1 month after treatment, ONN tended to reduce in non-smokers whereas to increase in smokers significantly.
Conclusion: Smoking reduced ONN, impaired treatment effect in reducing PPD, and changed the MMP-8 level in gingival crevicular fluid to NSPT.
Trial Registration: Identifier NCT04974502 in CLinicalTrials.gov.
(© 2023 The Authors.)
التعليقات: Erratum in: J Oral Biol Craniofac Res. 2024 Jul-Aug;14(4):353-354. (PMID: 38826838)
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فهرسة مساهمة: Keywords: Matrix metalloproteinase-8; Neutrophils; Nonsurgical periodontal debridement; Periodontal index; Periodontitis; Smoking
سلسلة جزيئية: ClinicalTrials.gov NCT04974502
تواريخ الأحداث: Date Created: 20230522 Latest Revision: 20240603
رمز التحديث: 20240603
مُعرف محوري في PubMed: PMC10193004
DOI: 10.1016/j.jobcr.2023.05.004
PMID: 37215391
قاعدة البيانات: MEDLINE
الوصف
تدمد:2212-4268
DOI:10.1016/j.jobcr.2023.05.004