دورية أكاديمية
Factors related to fetal demise in cases with congenital heart defects.
| العنوان: | Factors related to fetal demise in cases with congenital heart defects. |
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| المؤلفون: | Snoep MC; Department of Obstetrics and Fetal Medicine, Leiden University Medical Center, Leiden, The Netherlands (Drs. Snoep, Drs. Zwanenburg, and Prof. Haak). Electronic address: M.C.Snoep@lumc.nl., Bet BB; Department of Obstetrics and Fetal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands (Drs. Bet, Drs. Linskens, and Prof. Pajkrt)., Zwanenburg F; Department of Obstetrics and Fetal Medicine, Leiden University Medical Center, Leiden, The Netherlands (Drs. Snoep, Drs. Zwanenburg, and Prof. Haak)., Knobbe I; Department of Pediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands (Drs. Knobbe and Drs. Rozendaal)., Linskens IH; Department of Obstetrics and Fetal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands (Drs. Bet, Drs. Linskens, and Prof. Pajkrt)., Pajkrt E; Department of Obstetrics and Fetal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands (Drs. Bet, Drs. Linskens, and Prof. Pajkrt)., Rozendaal L; Department of Pediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands (Drs. Knobbe and Drs. Rozendaal)., Van der Meeren LE; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands (Drs. Van der Meeren); Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands (Drs. Van der Meeren)., Clur SA; Department of Pediatric Cardiology, Amsterdam University Medical Center, Amsterdam, The Netherlands (Drs. Clur)., Haak MC; Department of Obstetrics and Fetal Medicine, Leiden University Medical Center, Leiden, The Netherlands (Drs. Snoep, Drs. Zwanenburg, and Prof. Haak). |
| المصدر: | American journal of obstetrics & gynecology MFM [Am J Obstet Gynecol MFM] 2023 Aug; Vol. 5 (8), pp. 101023. Date of Electronic Publication: 2023 May 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101746609 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-9333 (Electronic) Linking ISSN: 25899333 NLM ISO Abbreviation: Am J Obstet Gynecol MFM Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [New York, NY] : Elsevier Inc., [2019]- |
| مواضيع طبية MeSH: | Placental Insufficiency*/epidemiology , Heart Defects, Congenital*/diagnostic imaging , Heart Defects, Congenital*/epidemiology , Fetal Diseases* , Heart Failure*, Child ; Pregnancy ; Female ; Humans ; Placenta ; Prospective Studies ; Fetal Death/etiology |
| مستخلص: | Background: Congenital heart defects are the most common congenital anomaly. Despite the increasing survival of these children, there is still an increased incidence of fetal demise, frequently attributed to cardiac failure. Considering that abnormal placental development has been described in congenital heart disease, our hypothesis is that placental insufficiency may contribute to fetal death in congenital heart disease. Objective: This study aimed to assess cases with fetal congenital heart disease and intrauterine demise, and analyze factors that are related to the demise. Study Design: All congenital heart disease cases diagnosed prenatally during the period January 2002 to January 2021 were selected from the regional prospective congenital heart disease registry, PRECOR. Multiple pregnancies and pregnancies with fetal trisomy 13 or 18, triploidy, and Turner's syndrome were excluded from the analysis, because fetal demise is attributed to the chromosomal abnormality in these cases. Cases were categorized into 4 groups based on the possible cause of fetal death as follows: cardiac failure, additional (genetic) diagnosis, placental insufficiency, and a group in which no cause was found. A separate analysis was performed for isolated congenital heart disease cases. Results: Of the 4806 cases in the PRECOR registry, 112 had fetal demise, of which 43 were excluded from the analysis (13 multiple pregnancies, 30 genetic). Of these, 47.8% were most likely related to cardiac failure, 42.0% to another (genetic) diagnosis, and 10.1% to placental insufficiency. No cases were allocated to the group with an unknown cause. Only 47.8% of the cases had isolated congenital heart disease, and in this group 21.2% was most likely related to placental insufficiency. Conclusion: This study shows that in addition to cardiac failure and other (genetic) diagnoses, placental factors play an important role in fetal demise in congenital heart disease, especially in cases of isolated heart defects. Therefore, these findings support the importance of regular ultrasonographic assessment of fetal growth and placental function in fetal congenital heart disease. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Am J Obstet Gynecol MFM. 2023 Sep;5(9):101071. (PMID: 37393031) Comment in: Am J Obstet Gynecol MFM. 2023 Sep;5(9):101070. (PMID: 37406988) |
| فهرسة مساهمة: | Keywords: congenital heart disease; fetal demise; placenta; stillbirth |
| تواريخ الأحداث: | Date Created: 20230523 Date Completed: 20230807 Latest Revision: 20230828 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ajogmf.2023.101023 |
| PMID: | 37220848 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2589-9333 |
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| DOI: | 10.1016/j.ajogmf.2023.101023 |