دورية أكاديمية
The Prognostic and Diagnostic Value of [ 18 F]FDG PET/CT in Untreated Laryngeal Carcinoma.
العنوان: | The Prognostic and Diagnostic Value of [ 18 F]FDG PET/CT in Untreated Laryngeal Carcinoma. |
---|---|
المؤلفون: | Al-Ibraheem A; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, Jordan.; Department of Radiology and Nuclear Medicine, Division of Nuclear Medicine, University of Jordan, Amman 11942, Jordan., Abdlkadir AS; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, Jordan., Al-Adhami D; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, Jordan., Hejleh TA; Department of Medical Oncology, King Hussein Cancer Center, Amman 11941, Jordan., Mansour A; Department of Diagnostic Radiology, King Hussein Cancer Center, Amman 11941, Jordan., Mohamad I; Department of Radiation Oncology, King Hussein Cancer Center, Amman 11941, Jordan., Juweid ME; Department of Radiology and Nuclear Medicine, Division of Nuclear Medicine, University of Jordan, Amman 11942, Jordan., Al-Rasheed U; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, Jordan., Al-Hajaj N; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, Jordan., Laban DA; Department of Diagnostic Radiology, King Hussein Cancer Center, Amman 11941, Jordan., Estrada-Lobato E; Nuclear Medicine and Diagnostic Section, Division of Human Health, International Atomic Energy Agency, 1220 Vienna, Austria., Saraireh O; Department of Surgical Oncology, King Hussein Cancer Center, Amman 11941, Jordan. |
المصدر: | Journal of clinical medicine [J Clin Med] 2023 May 17; Vol. 12 (10). Date of Electronic Publication: 2023 May 17. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2012]- |
مستخلص: | This study aims to determine the diagnostic accuracy of staging PET/CT and neck MRI in patients with laryngeal carcinoma and to assess the value of PET/CT in predicting progression-free survival (PFS) and overall survival (OS). Sixty-eight patients who had both modalities performed before treatment between 2014 and 2021 were included in this study. The sensitivity and specificity of PET/CT and MRI were evaluated. PET/CT had 93.8% sensitivity, 58.3% specificity, and 75% accuracy for nodal metastasis, whereas MRI had 68.8%, 61.1%, and 64.7% accuracy, respectively. At a median follow-up of 51 months, 23 patients had developed disease progression and 17 patients had died. Univariate-survival analysis revealed all utilized PET parameters as significant prognostic factors for OS and PFS ( p -value < 0.03 each). In multivariate analysis, metabolic-tumor volume (MTV) and total lesion glycolysis (TLG) predicted better PFS ( p -value < 0.05 each). In conclusion, PET/CT improves the accuracy of nodal staging in laryngeal carcinoma over neck MRI and adds to the prognostication of survival outcomes through the use of several PET metrics. |
References: | Otolaryngol Head Neck Surg. 2007 Jul;137(1):130-7. (PMID: 17599580) Surg Oncol. 2013 Jun;22(2):e11-6. (PMID: 23538049) AJNR Am J Neuroradiol. 2010 Apr;31(4):598-604. (PMID: 19910448) PET Clin. 2022 Apr;17(2):235-248. (PMID: 35260366) Clin Lung Cancer. 2018 Jan;19(1):e101-e108. (PMID: 28690012) J Nucl Med. 2014 Jun;55(6):884-90. (PMID: 24752671) Eur J Nucl Med Mol Imaging. 2016 Jul;43(7):1360-75. (PMID: 26780912) Medicine (Baltimore). 2021 Oct 8;100(40):e27427. (PMID: 34622853) Aging (Albany NY). 2020 Jul 16;12(14):14593-14619. (PMID: 32674074) Rev Esp Med Nucl Imagen Mol (Engl Ed). 2021 Jul-Aug;40(4):229-238. (PMID: 34218885) CA Cancer J Clin. 2017 Mar;67(2):122-137. (PMID: 28128848) Eur J Cancer. 2005 Mar;41(5):683-93. (PMID: 15763643) J Nucl Med. 2017 Dec;58(12):1919-1924. (PMID: 28572489) AJR Am J Roentgenol. 2017 Aug;209(2):289-303. (PMID: 28731808) Laryngoscope. 2018 Feb;128(2):378-385. (PMID: 28600822) J Natl Cancer Inst. 2008 May 21;100(10):712-20. (PMID: 18477804) Nucl Med Commun. 2018 Apr;39(4):334-342. (PMID: 29533345) J Nucl Med. 2011 Feb;52(2):180-7. (PMID: 21270454) Semin Ultrasound CT MR. 2019 Oct;40(5):376-390. (PMID: 31635765) Int J Biol Sci. 2021 Jan 1;17(2):475-486. (PMID: 33613106) Acta Otolaryngol. 2010 Jul;130(7):756-62. (PMID: 20085442) Oral Oncol. 2015 Apr;51(4):314-20. (PMID: 25619735) EJNMMI Res. 2019 Feb 7;9(1):14. (PMID: 30734113) PLoS One. 2022 Feb 25;17(2):e0264387. (PMID: 35213602) Radiology. 2014 Apr;271(1):153-61. (PMID: 24475791) CA Cancer J Clin. 2017 Jan;67(1):31-50. (PMID: 27898173) J Oncol. 2009;2009:208725. (PMID: 19707528) PLoS One. 2014 May 12;9(5):e96999. (PMID: 24818750) Int J Radiat Oncol Biol Phys. 2005 Jan 1;61(1):129-36. (PMID: 15629603) Nucl Med Commun. 2019 Apr;40(4):361-369. (PMID: 30664599) Clin Radiol. 2021 Jan;76(1):78.e9-78.e17. (PMID: 33036778) J Clin Oncol. 2018 Apr 10;36(11):1143-1169. (PMID: 29172863) Head Neck. 2016 Feb;38(2):290-3. (PMID: 25327765) Oral Oncol. 2009 Mar;45(3):234-40. (PMID: 18715818) BMC Med Imaging. 2023 Feb 22;23(1):34. (PMID: 36814217) Radiat Oncol. 2023 Jan 30;18(1):20. (PMID: 36710364) Oral Oncol. 2007 Oct;43(9):887-93. (PMID: 17207656) |
فهرسة مساهمة: | Keywords: MTV; PET/CT; TLG; [18F]FDG PET/CT vs. neck MRI; laryngeal squamous-cell carcinoma; metastatic lymph node; semiquantitative PET parameters |
تواريخ الأحداث: | Date Created: 20230527 Latest Revision: 20230530 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10218884 |
DOI: | 10.3390/jcm12103514 |
PMID: | 37240619 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2077-0383 |
---|---|
DOI: | 10.3390/jcm12103514 |