دورية أكاديمية
The Prognostic and Diagnostic Value of [ 18 F]FDG PET/CT in Untreated Laryngeal Carcinoma.
| العنوان: | The Prognostic and Diagnostic Value of [ 18 F]FDG PET/CT in Untreated Laryngeal Carcinoma. |
|---|---|
| المؤلفون: | Al-Ibraheem A; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, Jordan.; Department of Radiology and Nuclear Medicine, Division of Nuclear Medicine, University of Jordan, Amman 11942, Jordan., Abdlkadir AS; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, Jordan., Al-Adhami D; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, Jordan., Hejleh TA; Department of Medical Oncology, King Hussein Cancer Center, Amman 11941, Jordan., Mansour A; Department of Diagnostic Radiology, King Hussein Cancer Center, Amman 11941, Jordan., Mohamad I; Department of Radiation Oncology, King Hussein Cancer Center, Amman 11941, Jordan., Juweid ME; Department of Radiology and Nuclear Medicine, Division of Nuclear Medicine, University of Jordan, Amman 11942, Jordan., Al-Rasheed U; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, Jordan., Al-Hajaj N; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, Jordan., Laban DA; Department of Diagnostic Radiology, King Hussein Cancer Center, Amman 11941, Jordan., Estrada-Lobato E; Nuclear Medicine and Diagnostic Section, Division of Human Health, International Atomic Energy Agency, 1220 Vienna, Austria., Saraireh O; Department of Surgical Oncology, King Hussein Cancer Center, Amman 11941, Jordan. |
| المصدر: | Journal of clinical medicine [J Clin Med] 2023 May 17; Vol. 12 (10). Date of Electronic Publication: 2023 May 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2012]- |
| مستخلص: | This study aims to determine the diagnostic accuracy of staging PET/CT and neck MRI in patients with laryngeal carcinoma and to assess the value of PET/CT in predicting progression-free survival (PFS) and overall survival (OS). Sixty-eight patients who had both modalities performed before treatment between 2014 and 2021 were included in this study. The sensitivity and specificity of PET/CT and MRI were evaluated. PET/CT had 93.8% sensitivity, 58.3% specificity, and 75% accuracy for nodal metastasis, whereas MRI had 68.8%, 61.1%, and 64.7% accuracy, respectively. At a median follow-up of 51 months, 23 patients had developed disease progression and 17 patients had died. Univariate-survival analysis revealed all utilized PET parameters as significant prognostic factors for OS and PFS ( p -value < 0.03 each). In multivariate analysis, metabolic-tumor volume (MTV) and total lesion glycolysis (TLG) predicted better PFS ( p -value < 0.05 each). In conclusion, PET/CT improves the accuracy of nodal staging in laryngeal carcinoma over neck MRI and adds to the prognostication of survival outcomes through the use of several PET metrics. |
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| فهرسة مساهمة: | Keywords: MTV; PET/CT; TLG; [18F]FDG PET/CT vs. neck MRI; laryngeal squamous-cell carcinoma; metastatic lymph node; semiquantitative PET parameters |
| تواريخ الأحداث: | Date Created: 20230527 Latest Revision: 20230530 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10218884 |
| DOI: | 10.3390/jcm12103514 |
| PMID: | 37240619 |
| قاعدة البيانات: | MEDLINE |
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