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In Vivo Toxicity Assessment of the Probiotic Bacillus amyloliquefaciens HTI-19 Isolated from Stingless Bee ( Heterotrigona itama) Honey.

التفاصيل البيبلوغرافية
العنوان: In Vivo Toxicity Assessment of the Probiotic Bacillus amyloliquefaciens HTI-19 Isolated from Stingless Bee ( Heterotrigona itama) Honey.
المؤلفون: Zulkhairi Amin FA; Natural Medicines and Product Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia., Shafiq Cheng MZ; Natural Medicines and Product Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia., Sabri S; Enzyme and Microbial Technology Research Center, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia., Ismail N; Natural Medicines and Product Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia., Chan KW; Natural Medicines and Product Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia., Mohd Esa N; Natural Medicines and Product Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.; Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia., Mohd Lila MA; Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia., Nur-Fazila SH; Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia., Khalifa SAM; Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden., El-Seedi HR; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China.; International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu Education Department, Jiangsu University, Zhenjiang 212013, China., Zawawi N; Functional Carbohydrate and Protein Laboratory, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.; Laboratory of Halal Science, Halal Products Research Institute, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
المصدر: Nutrients [Nutrients] 2023 May 19; Vol. 15 (10). Date of Electronic Publication: 2023 May 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Honey* , Bacillus amyloliquefaciens* , Probiotics*, Bees ; Female ; Rats ; Animals ; Rats, Sprague-Dawley ; Body Weight
مستخلص: This study evaluated the acute and sub-acute toxicity of B. amyloliquefaciens HTI-19 (isolated from stingless bee honey) in female Sprague Dawley rats. In an acute toxicity study, the rats received a low dosage (1 × 10 9 CFU·mL -1 ), medium dosage (3 × 10 9 CFU·mL -1 ), or high dosage (1 × 10 10 CFU·mL -1 ) of B. amyloliquefaciens HTI-19 daily orally by syringe-feeding for 14 days. For the subacute toxicity study, rats received a low dosage (1 × 10 9 CFU·mL -1 ) or a high dosage (1 × 10 10 CFU·mL -1 ) for 28 days. The probiotic feeding in acute and sub-acute toxicity studies showed no mortality or significant abnormalities in rats throughout the experimental period. In week 2 of the acute study, the body weight of the rats showed a significant increase ( p < 0.05) compared to the control. By gross and microscopic examination of organs, no evidently significant changes were observed in the morphology of organs. Serum biochemical tests and blood hematology tests also revealed no treatment-related changes. Overall, these data indicated that oral administration of B. amyloliquefaciens HTI-19 up to 1 × 10 9 CFU·mL -1 for 28 days can be considered safe.
References: Food Chem Toxicol. 2011 Jan;49(1):251-8. (PMID: 21056609)
PLoS One. 2016 Jul 28;11(7):e0159851. (PMID: 27467068)
Food Chem. 2022 Mar 30;373(Pt B):131566. (PMID: 34823933)
Gut Microbes. 2010 May-Jun;1(3):164-85. (PMID: 21327023)
Adv Pharmacol Sci. 2018 Dec 26;2018:6179596. (PMID: 30687402)
Int J Toxicol. 2012 Jun;31(3):228-37. (PMID: 22674930)
Arerugi. 2020;69(1):19-22. (PMID: 32051365)
Benef Microbes. 2019 Oct 14;10(7):759-771. (PMID: 31965848)
Nutrients. 2022 Oct 07;14(19):. (PMID: 36235818)
ScientificWorldJournal. 2014;2014:928652. (PMID: 25379552)
PLoS One. 2017 Dec 20;12(12):e0189837. (PMID: 29261747)
Food Chem Toxicol. 2009 Jun;47(6):1231-8. (PMID: 19248815)
Nutrients. 2022 Jul 12;14(14):. (PMID: 35889814)
J Ethnopharmacol. 2014 Nov 18;157:285-91. (PMID: 25239833)
Biosci Microbiota Food Health. 2015;34(1):25-8. (PMID: 25625034)
Animal Model Exp Med. 2018 Nov 21;1(4):250-254. (PMID: 30891574)
Animals (Basel). 2022 Nov 07;12(21):. (PMID: 36359186)
PLoS One. 2019 Mar 22;14(3):e0213841. (PMID: 30901338)
Biomed Res Int. 2019 Oct 3;2019:5431354. (PMID: 31687392)
Front Microbiol. 2015 Feb 17;6:58. (PMID: 25741323)
Int J Food Microbiol. 2000 May 25;56(1):87-96. (PMID: 10857928)
PeerJ. 2019 Aug 22;7:e7478. (PMID: 31497388)
J Microbiol Biotechnol. 2022 Jan 28;32(1):46-55. (PMID: 34675143)
J Nutr. 1966 Dec;90(4):354-60. (PMID: 5954817)
Food Chem Toxicol. 2021 May;151:112124. (PMID: 33727180)
Int J Environ Res Public Health. 2019 Dec 31;17(1):. (PMID: 31906055)
معلومات مُعتمدة: TRGS/1/2016/UPM/01/5/4 Ministry of Education Malaysia
فهرسة مساهمة: Keywords: Sprague Dawley rat; functional foods; probiotic safety
تواريخ الأحداث: Date Created: 20230527 Date Completed: 20230529 Latest Revision: 20230529
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10220645
DOI: 10.3390/nu15102390
PMID: 37242273
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu15102390