دورية أكاديمية
[Progress on the mechanism of n-hexane induced toxic effects in vitro and in vivo].
| العنوان: | [Progress on the mechanism of n-hexane induced toxic effects in vitro and in vivo]. |
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| المؤلفون: | Zhang LJ; Guangdong Medical University School of Public Health, Shenzhen 518020, China Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen Health Toxicology Medical Key Discipline (2020-2024), Shenzhen 518020, China., Feng WT; Shenzhen Institute of Occupational Disease Control and Prevention, Occupational Health Care Institute Guangdong, Shenzhen 518020, China., Liu JJ; Guangdong Medical University School of Public Health, Shenzhen 518020, China Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen Health Toxicology Medical Key Discipline (2020-2024), Shenzhen 518020, China. |
| المصدر: | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases [Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi] 2023 May 20; Vol. 41 (5), pp. 388-396. |
| نوع المنشور: | Review; English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Tianjin shi lao dong wei sheng yan jiu suo ; Tianjin shi lao dong wei sheng huan jing yi xue hui Country of Publication: China NLM ID: 8410840 Publication Model: Print Cited Medium: Print ISSN: 1001-9391 (Print) Linking ISSN: 10019391 NLM ISO Abbreviation: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Tientsin] : Tianjin shi lao dong wei sheng yan jiu suo ; Tianjin shi lao dong wei sheng huan jing yi xue hui, [1983- |
| مواضيع طبية MeSH: | Hexanes*/toxicity , Hexanones*, Humans ; Industry ; Solvents |
| مستخلص: | Hexane is a widely used organic solvent in industry, and chronic hexane poisoning is the main occupational toxic lesion in China. In particular, axonal and myelin lesions in the distal thick fibers of the peripheral nervous system may be caused by 2, 5-hexanedione (2, 5-HD), an intermediate metabolite of n-hexane in humans. Hexane has toxic effects not only on the nervous system but also on the liver, kidneys, and reproductive organs. In this paper, we review the progress of research on the mechanism of n-hexane toxic neuropathy. |
| معلومات مُعتمدة: | JCYJ20190808175601651 Shenzhen Science and Technology Innovation Commission Basic Research Project; A2022438 Guangdong Medical Science and Technology Research Fund; SZXK069 Shenzhen Medical Key Discipline Construction Funding Project; SZSM201611090 Shenzhen Medical and Health Three Projects |
| فهرسة مساهمة: | Keywords: 2, 5-hexanedione; Chronic; Mechanism study; Toxic effects; n-hexane Local Abstract: [Publisher, Chinese] 正己烷是被广泛应用的一种有机溶剂，慢性正己烷中毒为我国主要的职业中毒之一。特别是周围神经系统远端粗纤维的轴索和髓鞘病变，可能由正己烷在人体内的中间代谢产物2，5-己二酮（2，5-HD）引起。正己烷不仅对神经系统有毒性作用，且有肝、肾和生殖性。本文以正己烷中毒性神经病变的机制研究进展进行综述。. |
| المشرفين على المادة: | 2DDG612ED8 (n-hexane) 0 (Hexanes) 0 (Hexanones) 0 (Solvents) |
| تواريخ الأحداث: | Date Created: 20230529 Date Completed: 20230531 Latest Revision: 20230531 |
| رمز التحديث: | 20230531 |
| DOI: | 10.3760/cma.j.cn121094-20220303-00109 |
| PMID: | 37248089 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1001-9391 |
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| DOI: | 10.3760/cma.j.cn121094-20220303-00109 |