دورية أكاديمية
Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP.
| العنوان: | Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP. |
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| المؤلفون: | Celik MÖ; Department of Experimental Anesthesiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Seitz V; Department of Experimental Anesthesiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Yergöz F; Department of Experimental Anesthesiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Dembla S; Department of Experimental Anesthesiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Blum NK; Department of Pharmacology, Universitätsklinikum Jena, Jena, Germany., Schulz S; Department of Pharmacology, Universitätsklinikum Jena, Jena, Germany., Stein C; Department of Experimental Anesthesiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. |
| المصدر: | Frontiers in molecular neuroscience [Front Mol Neurosci] 2023 May 12; Vol. 16, pp. 1171855. Date of Electronic Publication: 2023 May 12 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477914 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5099 (Print) Linking ISSN: 16625099 NLM ISO Abbreviation: Front Mol Neurosci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2008- |
| مستخلص: | N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide is a newly-designed pain killer selectively activating G-protein-coupled mu-opioid receptors (MOR) in acidic injured tissues, and therefore devoid of central side effects which are typically elicited at normal pH values in healthy tissues. However, the neuronal mechanisms underlying NFEPP's antinociceptive effects were not examined in detail so far. Voltage-dependent Ca 2+ channels (VDCCs) in nociceptive neurons play a major role in the generation and inhibition of pain. In this study, we focused on the effects of NFEPP on calcium currents in rat dorsal root ganglion (DRG) neurons. The inhibitory role of the G-protein subunits G Competing Interests: SS was the founder and scientific advisor of 7TM Antibodies GmbH, Jena, Germany. The Charité – Universitätsmedizin Berlin has filed a patent on pH-dependent opioid receptor agonists (US 9133120 B2). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Celik, Seitz, Yergöz, Dembla, Blum, Schulz and Stein.) |
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| فهرسة مساهمة: | Keywords: NFEPP; VDCC; fentanyl; mu opioid receptor (MOR); pain |
| تواريخ الأحداث: | Date Created: 20230530 Latest Revision: 20230531 |
| رمز التحديث: | 20230531 |
| مُعرف محوري في PubMed: | PMC10213447 |
| DOI: | 10.3389/fnmol.2023.1171855 |
| PMID: | 37251645 |
| قاعدة البيانات: | MEDLINE |
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