دورية أكاديمية
Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP.
العنوان: | Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP. |
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المؤلفون: | Celik MÖ; Department of Experimental Anesthesiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Seitz V; Department of Experimental Anesthesiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Yergöz F; Department of Experimental Anesthesiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Dembla S; Department of Experimental Anesthesiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Blum NK; Department of Pharmacology, Universitätsklinikum Jena, Jena, Germany., Schulz S; Department of Pharmacology, Universitätsklinikum Jena, Jena, Germany., Stein C; Department of Experimental Anesthesiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. |
المصدر: | Frontiers in molecular neuroscience [Front Mol Neurosci] 2023 May 12; Vol. 16, pp. 1171855. Date of Electronic Publication: 2023 May 12 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477914 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5099 (Print) Linking ISSN: 16625099 NLM ISO Abbreviation: Front Mol Neurosci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2008- |
مستخلص: | N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide is a newly-designed pain killer selectively activating G-protein-coupled mu-opioid receptors (MOR) in acidic injured tissues, and therefore devoid of central side effects which are typically elicited at normal pH values in healthy tissues. However, the neuronal mechanisms underlying NFEPP's antinociceptive effects were not examined in detail so far. Voltage-dependent Ca 2+ channels (VDCCs) in nociceptive neurons play a major role in the generation and inhibition of pain. In this study, we focused on the effects of NFEPP on calcium currents in rat dorsal root ganglion (DRG) neurons. The inhibitory role of the G-protein subunits G Competing Interests: SS was the founder and scientific advisor of 7TM Antibodies GmbH, Jena, Germany. The Charité – Universitätsmedizin Berlin has filed a patent on pH-dependent opioid receptor agonists (US 9133120 B2). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Celik, Seitz, Yergöz, Dembla, Blum, Schulz and Stein.) |
References: | Gut. 2022 Apr;71(4):695-704. (PMID: 33785555) PLoS One. 2013 Sep 12;8(9):e74706. (PMID: 24069332) Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:123-142. (PMID: 28968191) EMBO J. 2001 May 15;20(10):2349-56. (PMID: 11350923) Mol Pharmacol. 2019 May;95(5):463-467. (PMID: 30723091) Mol Pharmacol. 2015 Jun;87(6):890-906. (PMID: 25549669) Expert Opin Investig Drugs. 2018 Oct;27(10):765-775. (PMID: 30148648) Mol Pharmacol. 2003 Aug;64(2):202-10. (PMID: 12869624) Behav Pharmacol. 2020 Apr;31(2&3):136-158. (PMID: 32168025) Clin J Pain. 2014 Jul;30(7):630-8. (PMID: 24281279) Nature. 2003 Sep 4;425(6953):93-8. (PMID: 12955148) Neuropharmacology. 2022 Oct 1;217:109202. (PMID: 35917874) J Physiol. 2019 Mar;597(6):1661-1675. (PMID: 30578671) Anal Biochem. 1976 May 7;72:248-54. (PMID: 942051) Br J Pharmacol. 2015 Jan;172(2):311-6. (PMID: 24517854) Science. 2017 Mar 3;355(6328):966-969. (PMID: 28254944) PLoS Biol. 2010 Jun 29;8(6):e1000412. (PMID: 20613859) J Chem Inf Model. 2020 Jul 27;60(7):3566-3576. (PMID: 32491854) Br J Pharmacol. 2019 Dec;176(23):4510-4520. (PMID: 31355457) Cold Spring Harb Protoc. 2016 May 02;2016(5):. (PMID: 27140924) Brain Res. 1995 Oct 23;696(1-2):231-41. (PMID: 8574674) Front Pharmacol. 2018 Nov 29;9:1388. (PMID: 30555325) Sci Rep. 2019 Dec 18;9(1):19344. (PMID: 31852967) Expert Opin Ther Targets. 2017 Jul;21(7):695-703. (PMID: 28480765) Pain. 2018 Nov;159(11):2277-2284. (PMID: 29994988) J Neurosci. 2007 May 9;27(19):5092-104. (PMID: 17494695) Cell Mol Neurobiol. 2021 Jul;41(5):839-847. (PMID: 32514826) Pain. 2014 Oct;155(10):2056-62. (PMID: 25046272) Int Rev Psychiatry. 2018 Oct;30(5):107-116. (PMID: 30522374) Neuropharmacology. 2018 Mar 15;131:238-255. (PMID: 29273520) EMBO Mol Med. 2013 Aug;5(8):1263-77. (PMID: 23818182) Sci Rep. 2018 Jun 12;8(1):8965. (PMID: 29895890) Pain. 2011 Jun;152(6):1238-1248. (PMID: 21295407) Reg Anesth Pain Med. 2020 Nov;45(11):907-916. (PMID: 32928995) Elife. 2017 Aug 15;6:. (PMID: 28826482) ACS Med Chem Lett. 2019 Aug 13;10(9):1353-1356. (PMID: 31531209) |
فهرسة مساهمة: | Keywords: NFEPP; VDCC; fentanyl; mu opioid receptor (MOR); pain |
تواريخ الأحداث: | Date Created: 20230530 Latest Revision: 20230531 |
رمز التحديث: | 20230531 |
مُعرف محوري في PubMed: | PMC10213447 |
DOI: | 10.3389/fnmol.2023.1171855 |
PMID: | 37251645 |
قاعدة البيانات: | MEDLINE |
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