دورية أكاديمية

(Zebra)fishing for nephrogenesis genes.

التفاصيل البيبلوغرافية
العنوان: (Zebra)fishing for nephrogenesis genes.
المؤلفون: Chambers BE; Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, Indiana (IN), USA., Weaver NE; Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, Indiana (IN), USA., Lara CM; Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, Indiana (IN), USA., Nguyen TK; Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, Indiana (IN), USA., Wingert RA; Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, Indiana (IN), USA.
المصدر: Tissue barriers [Tissue Barriers] 2024 Apr 02; Vol. 12 (2), pp. 2219605. Date of Electronic Publication: 2023 May 31.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101601065 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2168-8370 (Electronic) Linking ISSN: 21688362 NLM ISO Abbreviation: Tissue Barriers Subsets: MEDLINE
أسماء مطبوعة: Publication: Oct. 2014- : Abingdon, Oxfordshire, OX : Taylor & Francis
Original Publication: [Austin, TX ] : Landes Bioscience
مواضيع طبية MeSH: Zebrafish*, Animals ; Kidney/metabolism ; Organogenesis/genetics ; Humans
مستخلص: Kidney disease is a devastating condition affecting millions of people worldwide, where over 100,000 patients in the United States alone remain waiting for a lifesaving organ transplant. Concomitant with a surge in personalized medicine, single-gene mutations, and polygenic risk alleles have been brought to the forefront as core causes of a spectrum of renal disorders. With the increasing prevalence of kidney disease, it is imperative to make substantial strides in the field of kidney genetics. Nephrons, the core functional units of the kidney, are epithelial tubules that act as gatekeepers of body homeostasis by absorbing and secreting ions, water, and small molecules to filter the blood. Each nephron contains a series of proximal and distal segments with explicit metabolic functions. The embryonic zebrafish provides an ideal platform to systematically dissect the genetic cues governing kidney development. Here, we review the use of zebrafish to discover nephrogenesis genes.
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فهرسة مساهمة: Keywords: kidney; nephrogenesis; nephron; renal progenitor; segmentation; zebrafish
تواريخ الأحداث: Date Created: 20230531 Date Completed: 20240424 Latest Revision: 20240625
رمز التحديث: 20240625
مُعرف محوري في PubMed: PMC11042071
DOI: 10.1080/21688370.2023.2219605
PMID: 37254823
قاعدة البيانات: MEDLINE