التفاصيل البيبلوغرافية
| العنوان: |
l-Anserine Increases Muscle Differentiation and Muscle Contractility in Human Skeletal Muscle Cells. |
| المؤلفون: |
Nagai A; Institute for Health Care Science, Suntory Wellness Ltd., 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan.; Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan., Ida M; Institute for Health Care Science, Suntory Wellness Ltd., 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan., Izumo T; Institute for Health Care Science, Suntory Wellness Ltd., 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan., Nakai M; Institute for Health Care Science, Suntory Wellness Ltd., 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan., Honda H; Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan., Shimizu K; Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. |
| المصدر: |
Journal of agricultural and food chemistry [J Agric Food Chem] 2023 Jun 14; Vol. 71 (23), pp. 8952-8958. Date of Electronic Publication: 2023 May 31. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: |
Anserine*/analysis , Anserine*/pharmacology , Muscle Fibers, Skeletal*, Humans ; Muscle, Skeletal ; Muscle Contraction ; Cell Differentiation |
| مستخلص: |
l-Anserine, an imidazole peptide, has a variety of physiological activities, but its effects on skeletal muscle differentiation and muscle contractile force remain unknown. Thus, in this study, we investigated the effect of l-anserine on muscle differentiation and muscle contractile force in human skeletal muscle cells. In two-dimensional culture, 1 μM l-anserine significantly increased the myotube diameters (26.5 ± 1.71, 27.7 ± 1.08, and 28.8 ± 0.85 μm with 0, 0.1, and 1 μM l-anserine, respectively) and the expression levels of genes involved in muscle differentiation and the sarcomere structure. In three-dimensional culture, 1 μM l-anserine significantly increased the contractile force of engineered human skeletal muscle tissues cultured on a microdevice (1.99 ± 0.30, 2.17 ± 0.62, 2.66 ± 0.39, and 3.28 ± 0.85 μN with 0, 0.1, 0.5, and 1 μM l-anserine, respectively). l-Anserine also increased the myotube diameters and the proportion of myotubes with sarcomere structures in the cultured tissues. Furthermore, the histamine receptor 1 (H1R) antagonist attenuated the l-anserine-induced increase in the contractile force, suggesting the involvement of H1R in the mechanism of action of l-anserine. This study showed for the first time that l-anserine enhances muscle differentiation and muscle contractility via H1R. |
| فهرسة مساهمة: |
Keywords: contractile force; histamine receptor; l-anserine; microdevice; three-dimensional skeletal muscle tissue |
| المشرفين على المادة: |
HDQ4N37UGV (Anserine) |
| تواريخ الأحداث: |
Date Created: 20230531 Date Completed: 20230615 Latest Revision: 20230615 |
| رمز التحديث: |
20230615 |
| DOI: |
10.1021/acs.jafc.3c01685 |
| PMID: |
37255271 |
| قاعدة البيانات: |
MEDLINE |
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