دورية أكاديمية
Adenovirus is Not Detected in Liver Tissue From a Historical Multicenter Cohort of Children With Acute Liver Failure.
| العنوان: | Adenovirus is Not Detected in Liver Tissue From a Historical Multicenter Cohort of Children With Acute Liver Failure. |
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| المؤلفون: | Chapin CA; From the Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, IL., Diamond T; Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Harris RM; Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Vaccaro O; Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Loomes KM; Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Alonso EM; From the Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, IL., Behrens EM; Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. |
| المصدر: | Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2023 Sep 01; Vol. 77 (3), pp. 393-395. Date of Electronic Publication: 2023 May 31. |
| نوع المنشور: | Multicenter Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8211545 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-4801 (Electronic) Linking ISSN: 02772116 NLM ISO Abbreviation: J Pediatr Gastroenterol Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : Philadelphia, PA : Lippincott Williams & Wilkins Original Publication: [New York, N.Y.] : Raven Press, [c1982- |
| مواضيع طبية MeSH: | Liver Failure, Acute*/diagnosis , Liver Failure, Acute*/etiology , Hepatitis*/complications, Child ; Humans ; Adenoviridae ; Acute Disease |
| مستخلص: | There has been a recent surge in cases of pediatric acute hepatitis and pediatric acute liver failure (PALF) of unknown cause. Several reports have described clusters of these children who were positive for adenovirus (AdV) DNA, primarily in peripheral blood but some in liver tissue. We tested archived liver tissue specimens from a historical cohort of 44 children with PALF who were enrolled in a multicenter biorepository between 2007 and 2014 for AdV 40/41 using quantitative polymerase chain reaction. Most children had final diagnosis indeterminate. All samples were negative. Our findings suggest that AdV was unlikely to be an unidentified cause of indeterminate PALF during this past era. The significance of AdV viremia in contemporary cohorts of children with PALF remains unknown and requires further study. Competing Interests: The authors report no conflicts of interest. (Copyright © 2023 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.) |
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| معلومات مُعتمدة: | KL2 TR001879 United States TR NCATS NIH HHS; U01 DK072146 United States DK NIDDK NIH HHS |
| تواريخ الأحداث: | Date Created: 20230531 Date Completed: 20230821 Latest Revision: 20240902 |
| رمز التحديث: | 20240902 |
| مُعرف محوري في PubMed: | PMC11017675 |
| DOI: | 10.1097/MPG.0000000000003851 |
| PMID: | 37256853 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-4801 |
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| DOI: | 10.1097/MPG.0000000000003851 |