دورية أكاديمية
أعرض في EDS

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis.

التفاصيل البيبلوغرافية
العنوان: Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis.
المؤلفون: Nakajima-Takagi Y; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan., Oshima M; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan., Takano J; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Koide S; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan., Itokawa N; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan., Uemura S; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan., Yamashita M; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan., Andoh S; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan., Aoyama K; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan., Isshiki Y; Department of Cellular and Molecular Medicine, Chiba University, Chiba, Japan., Shinoda D; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan., Saraya A; Department of Cellular and Molecular Medicine, Chiba University, Chiba, Japan., Arai F; Department of Stem Cell Biology and Medicine, Kyushu University, Fukuoka, Japan., Yamaguchi K; Division of Clinical Genome Research,Advanced Clinical Research Center, The Institute of Medical Science, University of Tokyo, Tokyo, Japan., Furukawa Y; Division of Clinical Genome Research,Advanced Clinical Research Center, The Institute of Medical Science, University of Tokyo, Tokyo, Japan., Koseki H; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Ikawa T; Division of Immunobiology, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan., Iwama A; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.; Laboratoty of Cellular and Molecular Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
المصدر: ELife [Elife] 2023 Jun 02; Vol. 12. Date of Electronic Publication: 2023 Jun 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Polycomb Repressive Complex 1*/metabolism , Myelopoiesis*/genetics, Animals ; Mice ; Histones ; Cell Differentiation/physiology ; Hematopoietic Stem Cells/metabolism
مستخلص: Polycomb repressive complex (PRC) 1 regulates stem cell fate by mediating mono-ubiquitination of histone H2A at lysine 119. While canonical PRC1 is critical for hematopoietic stem and progenitor cell (HSPC) maintenance, the role of non-canonical PRC1 in hematopoiesis remains elusive. PRC1.1, a non-canonical PRC1, consists of PCGF1, RING1B, KDM2B, and BCOR. We recently showed that PRC1.1 insufficiency induced by the loss of PCGF1 or BCOR causes myeloid-biased hematopoiesis and promotes transformation of hematopoietic cells in mice. Here we show that PRC1.1 serves as an epigenetic switch that coordinates homeostatic and emergency hematopoiesis. PRC1.1 maintains balanced output of steady-state hematopoiesis by restricting C/EBPα-dependent precocious myeloid differentiation of HSPCs and the HOXA9- and β-catenin-driven self-renewing network in myeloid progenitors. Upon regeneration, PRC1.1 is transiently inhibited to facilitate formation of granulocyte-macrophage progenitor (GMP) clusters, thereby promoting emergency myelopoiesis. Moreover, constitutive inactivation of PRC1.1 results in unchecked expansion of GMPs and eventual transformation. Collectively, our results define PRC1.1 as a novel critical regulator of emergency myelopoiesis, dysregulation of which leads to myeloid transformation.
Competing Interests: YN, MO, JT, SK, NI, SU, MY, SA, KA, YI, DS, AS, FA, KY, YF, HK, TI, AI No competing interests declared
(© 2023, Nakajima-Takagi et al.)
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معلومات مُعتمدة: 19H05653 Japan Society for the Promotion of Science; 20K08728 Japan Society for the Promotion of Science; 19H05746 Japan Society for the Promotion of Science; 21zf0127003h0001 Japan Agency for Medical Research and Development; JP223fa627001 Japan Agency for Medical Research and Development
فهرسة مساهمة: Keywords: emergency myelopoiesis; hematopoietic stem; mouse; myelopoiesis; polycomb repressive complex 1.1; progenitor cell; regenerative medicine; stem cells
المشرفين على المادة: EC 2.3.2.27 (Polycomb Repressive Complex 1)
0 (Histones)
تواريخ الأحداث: Date Created: 20230602 Date Completed: 20230626 Latest Revision: 20231116
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10287155
DOI: 10.7554/eLife.83004
PMID: 37266576
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.83004