دورية أكاديمية
أعرض في EDS

The toxins of vertically transmitted Spiroplasma .

التفاصيل البيبلوغرافية
العنوان: The toxins of vertically transmitted Spiroplasma .
المؤلفون: Moore LD; Department of Biological Sciences, Mississippi State University, Mississippi State, MS, United States., Ballinger MJ; Department of Biological Sciences, Mississippi State University, Mississippi State, MS, United States.
المصدر: Frontiers in microbiology [Front Microbiol] 2023 May 18; Vol. 14, pp. 1148263. Date of Electronic Publication: 2023 May 18 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101548977 Publication Model: eCollection Cited Medium: Print ISSN: 1664-302X (Print) Linking ISSN: 1664302X NLM ISO Abbreviation: Front Microbiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Vertically transmitted (VT) microbial symbionts play a vital role in the evolution of their insect hosts. A longstanding question in symbiont research is what genes help promote long-term stability of vertically transmitted lifestyles. Symbiont success in insect hosts is due in part to expression of beneficial or manipulative phenotypes that favor symbiont persistence in host populations. In Spiroplasma , these phenotypes have been linked to toxin and virulence domains among a few related strains. However, these domains also appear frequently in phylogenetically distant Spiroplasma, and little is known about their distribution across the Spiroplasma genus. In this study, we present the complete genome sequence of the Spiroplasma symbiont of Drosophila atripex , a non-manipulating member of the Ixodetis clade of Spiroplasma , for which genomic data are still limited. We perform a genus-wide comparative analysis of toxin domains implicated in defensive and reproductive phenotypes. From 12 VT and 31 non-VT Spiroplasma genomes, ribosome-inactivating proteins (RIPs), OTU-like cysteine proteases (OTUs), ankyrins, and ETX/MTX2 domains show high propensity for VT Spiroplasma compared to non-VT Spiroplasma . Specifically, OTU and ankyrin domains can be found only in VT- Spiroplasma , and RIP domains are found in all VT Spiroplasma and three non-VT Spiroplasma . These domains are frequently associated with Spiroplasma plasmids, suggesting a possible mechanism for dispersal and maintenance among heritable strains. Searching insect genome assemblies available on public databases uncovered uncharacterized Spiroplasma genomes from which we identified several spaid -like genes encoding RIP, OTU, and ankyrin domains, suggesting functional interactions among those domain types. Our results suggest a conserved core of symbiont domains play an important role in the evolution and persistence of VT Spiroplasma in insects.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Moore and Ballinger.)
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فهرسة مساهمة: Keywords: ETX/MTX2; Ixodetis; OTU-like cysteine protease; Spiroplasma; ankyrin; ribosome-inactivating proteins; vertical transmission
تواريخ الأحداث: Date Created: 20230605 Latest Revision: 20230919
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10232968
DOI: 10.3389/fmicb.2023.1148263
PMID: 37275155
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-302X
DOI:10.3389/fmicb.2023.1148263