دورية أكاديمية
Pediatric hepatic vascular tumors: clinicopathologic characteristics of 33 cases and proposed updates to current classification schemes.
| العنوان: | Pediatric hepatic vascular tumors: clinicopathologic characteristics of 33 cases and proposed updates to current classification schemes. |
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| المؤلفون: | Berklite L; Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; University of Cincinnati, Department of Pathology, UC Health University Hospital, Laboratory Medicine Building, Cincinnati, OH 45219, USA. Electronic address: lara.berklite@cchmc.org., Malik F; Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: Faizan.malik@pennmedicine.upenn.edu., Ranganathan S; Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; University of Cincinnati, Department of Pathology, UC Health University Hospital, Laboratory Medicine Building, Cincinnati, OH 45219, USA. Electronic address: sarangarajan.ranganathan@cchmc.org., Gupta A; Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. |
| المصدر: | Human pathology [Hum Pathol] 2023 Nov; Vol. 141, pp. 78-89. Date of Electronic Publication: 2023 Jun 03. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: W B Saunders Country of Publication: United States NLM ID: 9421547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8392 (Electronic) Linking ISSN: 00468177 NLM ISO Abbreviation: Hum Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia, PA : W B Saunders Original Publication: Philadelphia, W B. Saunders Co. |
| مواضيع طبية MeSH: | Vascular Neoplasms*/pathology , Hemangioma*/pathology , Liver Neoplasms*/pathology , Hemangiosarcoma*/therapy , Hemangiosarcoma*/pathology , Neoplasms, Vascular Tissue*, Male ; Humans ; Child ; Child, Preschool |
| مستخلص: | Pediatric hepatic vascular tumors (HVTs) are rare neoplasms with features distinct from their cutaneous counterparts. Their behavior ranges from benign to malignant, with each subtype having therapeutic differences. Histopathologic descriptions of large cohorts are scarce in the literature. Thirty-three putative HVTs diagnosed from 1970 to 2021 were retrieved. All available clinical and pathologic materials were reviewed. Lesions were reclassified according to the World Health Organization (WHO) classification of pediatric tumors [1] as hepatic congenital hemangioma (HCH; n = 13), hepatic infantile hemangioma (HIH; n = 10), hepatic angiosarcoma (HA; n = 3), and hepatic epithelioid hemangioendothelioma (HEH; n = 1). Vascular malformations (n = 5) or vascular-dominant mesenchymal hamartoma (n = 1) were excluded. HCH frequently showed involutional changes, whereas HIH often had anastomosing channels and pseudopapillae formation. HA had solid areas with epithelioid and/or spindled endothelial morphology, significant atypia, increased mitoses, high proliferation index, and occasionally necrosis. On morphology analysis, a subset of HIH showed features worrisome for progression to HA including solid glomeruloid proliferation, increased mitoses, and epithelioid morphology. The widely metastatic and fatal HEH was observed in a 5-year-old male with multiple liver lesions. Immunohistochemically, HIHs and HA were Glucose transporter isoform 1 (GLUT-1) positive. One HIH patient died from postoperative complications, whereas 3 are alive without disease. Five HCH patients are alive and well. Two of three HA patients died of disease, and 1 is alive without recurrence. To our knowledge, this is the largest series of pediatric HVTs reviewing clinicopathologic features based on current Pediatric WHO nomenclature [1]. We highlight diagnostic challenges and propose inclusion of an intermediate category between HIH and HA which warrants closer follow-up. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Angiosarcoma; Congenital hemangioma; Hemangoendothelioma; Infantile hemangioma; Liver; Vascular tumors |
| تواريخ الأحداث: | Date Created: 20230605 Date Completed: 20231128 Latest Revision: 20231128 |
| رمز التحديث: | 20231128 |
| DOI: | 10.1016/j.humpath.2023.05.013 |
| PMID: | 37277077 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-8392 |
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| DOI: | 10.1016/j.humpath.2023.05.013 |