دورية أكاديمية
Caging the Hofmeister Effect by a Biomimetic Supramolecular Receptor.
| العنوان: | Caging the Hofmeister Effect by a Biomimetic Supramolecular Receptor. |
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| المؤلفون: | Lin W; Chemistry Program, Physical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia., Zhang G; Chemistry Program, Physical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.; Advanced Membranes and Porous Materials Center (AMPM), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia., Zhu X; Chemistry Program, Physical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia., Yu P; Chemistry Program, Physical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia., Alimi LO; Chemistry Program, Physical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia., Moosa BA; Chemistry Program, Physical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.; Advanced Membranes and Porous Materials Center (AMPM), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia., Sessler JL; Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712-1224, United States., Khashab NM; Chemistry Program, Physical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.; Advanced Membranes and Porous Materials Center (AMPM), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. |
| المصدر: | Journal of the American Chemical Society [J Am Chem Soc] 2023 Jun 14; Vol. 145 (23), pp. 12609-12616. Date of Electronic Publication: 2023 Jun 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : American Chemical Society Original Publication: Easton, Pa. [etc.] |
| مواضيع طبية MeSH: | Biomimetics* , Proteins*, Anions ; Chlorides ; Water |
| مستخلص: | The effect of anions on the solubility and function of proteins was recognized in 1888 and is now termed the Hofmeister effect. Numerous synthetic receptors are known that overcome the associated anion recognition bias. However, we are unaware of a synthetic host being used to overcome Hofmeister effect perturbations to natural proteins. Here, we report a protonated small molecule cage complex that acts as an exo-receptor and displays non-Hofmeister solubility behavior, with only the chloride complex remaining soluble in aqueous media. This cage allows for the activity of lysozyme to be retained under conditions where anion-induced precipitation would otherwise cause it to be lost. To our knowledge, this is the first time a synthetic anion receptor is used to overcome the Hofmeister effect in a biological system. |
| المشرفين على المادة: | 0 (Anions) 0 (Proteins) 0 (Chlorides) 059QF0KO0R (Water) |
| تواريخ الأحداث: | Date Created: 20230606 Date Completed: 20230615 Latest Revision: 20230615 |
| رمز التحديث: | 20230615 |
| DOI: | 10.1021/jacs.3c01849 |
| PMID: | 37277952 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5126 |
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| DOI: | 10.1021/jacs.3c01849 |