دورية أكاديمية
أعرض في EDS

Fatigue in Patients with Newly Diagnosed Inflammatory Bowel Disease: Results from a Prospective Inception Cohort, the IBSEN III Study.

التفاصيل البيبلوغرافية
العنوان: Fatigue in Patients with Newly Diagnosed Inflammatory Bowel Disease: Results from a Prospective Inception Cohort, the IBSEN III Study.
المؤلفون: Holten KIA; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Østfold Hospital Trust, Sarpsborg, Norway., Bernklev T; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Research and Development Department, Vestfold Hospital Trust, Tønsberg, Norway., Opheim R; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.; Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway., Johansen I; Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Health Sciences, Østfold University College, Halden, Norway., Olsen BC; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway., Lund C; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Strande V; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.; Department of Gastroenterology, Lovisenberg Diaconal Hospital, Oslo, Norway., Medhus AW; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Perminow G; Pediatric Department, Oslo University Hospital, Oslo, Norway., Bengtson MB; Department of Medicine, Vestfold Hospital Trust, Tønsberg, Norway., Cetinkaya RB; Department of Medicine, Diakonhjemmet Hospital, Oslo, Norway., Vatn S; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway., Frigstad SO; Department of Medicine, Vestre Viken Hospital Trust, Bærum, Norway., Aabrekk TB; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Medicine, Vestfold Hospital Trust, Tønsberg, Norway., Detlie TE; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway., Hovde Ø; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Medicine, Innlandet Hospital Trust, Gjøvik, Norway., Kristensen VA; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Småstuen MC; Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway., Henriksen M; Department of Gastroenterology, Østfold Hospital Trust, Sarpsborg, Norway., Huppertz-Hauss G; Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway., Høivik ML; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Jelsness-Jørgensen LP; Department of Gastroenterology, Østfold Hospital Trust, Sarpsborg, Norway.; Department of Health Sciences, Østfold University College, Halden, Norway.
المصدر: Journal of Crohn's & colitis [J Crohns Colitis] 2023 Nov 24; Vol. 17 (11), pp. 1781-1790.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101318676 Publication Model: Print Cited Medium: Internet ISSN: 1876-4479 (Electronic) Linking ISSN: 18739946 NLM ISO Abbreviation: J Crohns Colitis Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Oxford : Oxford University Press
Original Publication: Amsterdam : Elsevier Science
مواضيع طبية MeSH: Colitis, Ulcerative*/diagnosis , Crohn Disease*/complications , Crohn Disease*/diagnosis , Crohn Disease*/epidemiology , Inflammatory Bowel Diseases*/complications , Inflammatory Bowel Diseases*/diagnosis , Inflammatory Bowel Diseases*/epidemiology, Adolescent ; Humans ; Fatigue/epidemiology ; Fatigue/etiology ; Fatigue/diagnosis ; Prospective Studies ; Adult
مستخلص: Background and Aims: Although fatigue is common in inflammatory bowel disease [IBD], its pathogenesis remains unclear. This study aimed to determine the prevalence of fatigue and its associated factors in a cohort of patients newly diagnosed with IBD.
Methods: Patients ≥18 years old were recruited from the Inflammatory Bowel Disease South-Eastern Norway [IBSEN III] study, a population-based, observational inception cohort. Fatigue was assessed using the Fatigue Questionnaire and compared with data from a Norwegian general population. Univariate and multivariate linear and logistic regression analyses were performed to evaluate the associations of total fatigue [TF; continuous score] and substantial fatigue [SF; dichotomized score ≥4] with sociodemographic, clinical, endoscopic, laboratory, and other relevant patient data.
Results: In total, 983/1509 [65.1%] patients with complete fatigue data were included (ulcerative colitis [UC], 68.2%; Crohn's disease [CD], 31.8%). The prevalence of SF was higher in CD [69.6%] compared with UC [60.2%] [p < 0.01], and in both diagnoses when compared to the general population [p < 0.001]. In multivariate analyses, depressive symptoms, pain intensity, and sleep disturbances were associated with increased TF for both diagnoses. In addition, increased clinical disease activity and Mayo endoscopic score were significantly associated with TF in UC, whereas all disease-related variables were insignificant in CD. Similar findings were observed for SF, except regarding the Mayo endoscopic score.
Conclusions: SF affects approximately two-thirds of patients newly diagnosed with IBD. Fatigue was associated with depressive symptoms, sleep disturbances, and increased pain intensity in both diagnoses, while clinical and endoscopic activity were associated factors only in UC.
(© The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation.)
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فهرسة مساهمة: Keywords: Inflammatory bowel disease; epidemiology; fatigue
تواريخ الأحداث: Date Created: 20230606 Date Completed: 20231130 Latest Revision: 20231130
رمز التحديث: 20231130
مُعرف محوري في PubMed: PMC10673818
DOI: 10.1093/ecco-jcc/jjad094
PMID: 37279652
قاعدة البيانات: MEDLINE
الوصف
تدمد:1876-4479
DOI:10.1093/ecco-jcc/jjad094