دورية أكاديمية
أعرض في EDS

Correlation between Serum Vitamin D3 Levels and Severity of COVID-19, Experience from a COVID-19-Dedicated Tertiary Care Hospital from Western India.

التفاصيل البيبلوغرافية
العنوان: Correlation between Serum Vitamin D3 Levels and Severity of COVID-19, Experience from a COVID-19-Dedicated Tertiary Care Hospital from Western India.
المؤلفون: Sanamandra P; Department of Endocrinology, Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India., Gada JV; Department of Endocrinology, Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India., Misra S; Department of Endocrinology, Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India., Barasara SA; Department of Endocrinology, Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India., Varthakavi PK; Department of Endocrinology, Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India., Bhagwat NM; Department of Endocrinology, Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India.
المصدر: Indian journal of endocrinology and metabolism [Indian J Endocrinol Metab] 2023 Mar-Apr; Vol. 27 (2), pp. 170-176. Date of Electronic Publication: 2023 Apr 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medknow Publications] Country of Publication: India NLM ID: 101555690 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2230-8210 (Print) Linking ISSN: 22309500 NLM ISO Abbreviation: Indian J Endocrinol Metab Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Mumbai, India : Medknow Publications], 1997-
مستخلص: Context: It is postulated that 25(OH)D deficiency is associated with a worse prognosis of COVID-19.
Aims: We aimed to find out whether baseline serum 25-hydroxy vitamin D levels were correlated with COVID-19 disease severity or not in Indian population.
Settings and Design: It is a prospective observational study.
Methods and Material: We prospectively recruited 200 COVID-19-positive adult patients and measured their baseline vitamin D levels on admission and prospectively followed their clinical course for their outcome and correlated the association.
Statistical Analysis Used: The continuous data were represented as mean (±SD) or median (IQR), while the categorical data were represented as proportions. Parametric data were analysed using unpaired T -test and ANOVA for two and more than two groups, and for categorical, nonparametric data, Chi-square test were applied. A two-sided P value of <0.05 was considered as statistically significant with 95% confidence interval.
Results: Eighty-six per cent (172/200) of patients had hypovitaminosis D (<30 ng/mL). The prevalence of 25(OH) severe deficiency, deficiency and vitamin D insufficiency was 23%, 41% and 22%, respectively. Clinical severity was graded as asymptomatic (11%), mild (14%), moderate (14.5%), severe (37.5%) and critical (22%). Sixty per cent of patients had clinically severe or critical disease requiring oxygen support with eleven per cent ( n = 22) mortality overall. Age ( P : 0.001), HTN ( P : 0.049) and DM ( P : 0.018) were negatively associated with clinical severity. No linear association was found between vitamin D levels and clinical severity. Low vitamin D levels had a significant inverse association with inflammatory markers like neutrophil-lymphocyte ratio (NLR, P : 0.012) and IL-6 ( P : 0.002).
Conclusions: Vitamin D deficiency was not associated with worse outcomes of COVID-19 infection in Indian population.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2023 Indian Journal of Endocrinology and Metabolism.)
References: Aging Clin Exp Res. 2020 Oct;32(10):2141-2158. (PMID: 32876941)
J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. (PMID: 21646368)
Nutrients. 2020 Sep 11;12(9):. (PMID: 32932831)
J Cell Biochem. 2017 Dec;118(12):4317-4322. (PMID: 28425575)
Sci Rep. 2017 Jun 12;7(1):3312. (PMID: 28607392)
Nutrients. 2020 Sep 10;12(9):. (PMID: 32927735)
Arch Med Sci. 2016 Aug 1;12(4):721-7. (PMID: 27478451)
Int J Infect Dis. 2021 Jun;107:264-267. (PMID: 33940189)
Curr Rheumatol Rep. 2008 Apr;10(2):110-7. (PMID: 18460265)
Vitam Horm. 2011;86:217-37. (PMID: 21419273)
J Clin Endocrinol Metab. 2022 Apr 19;107(5):1484-1502. (PMID: 34894254)
Cell Mol Immunol. 2016 Jan;13(1):3-10. (PMID: 26189369)
PLoS One. 2020 Sep 25;15(9):e0239799. (PMID: 32976513)
Virus Res. 2020 Nov;289:198148. (PMID: 32866536)
Indian J Endocrinol Metab. 2021 Jul-Aug;25(4):261-282. (PMID: 35136732)
Immunology. 2011 Oct;134(2):123-39. (PMID: 21896008)
J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1343-e1353. (PMID: 34932810)
Sci Rep. 2020 Nov 19;10(1):20191. (PMID: 33214648)
Nutrients. 2020 May 09;12(5):. (PMID: 32397511)
Circ Res. 2020 May 8;126(10):1456-1474. (PMID: 32264791)
J Diabetes Investig. 2021 Feb;12(2):254-265. (PMID: 32593190)
Sci Rep. 2021 Mar 18;11(1):6258. (PMID: 33737631)
J Am Coll Nutr. 2021 Nov-Dec;40(8):724-731. (PMID: 33048028)
Int J Gen Med. 2022 Jan 07;15:343-352. (PMID: 35027842)
JAMA. 2006 Dec 20;296(23):2832-8. (PMID: 17179460)
Eur Rev Med Pharmacol Sci. 2016 Jul;20(13):2916-9. (PMID: 27424994)
Crit Care. 2020 Jul 13;24(1):422. (PMID: 32660650)
J Family Med Prim Care. 2018 Mar-Apr;7(2):324-330. (PMID: 30090772)
فهرسة مساهمة: Keywords: COVID-19; inflammation; neutrophil–lymphocyte ratio; vitamin D deficiency
تواريخ الأحداث: Date Created: 20230609 Latest Revision: 20231031
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10245312
DOI: 10.4103/ijem.ijem_383_22
PMID: 37292066
قاعدة البيانات: MEDLINE
الوصف
تدمد:2230-8210
DOI:10.4103/ijem.ijem_383_22